Analysis of metal-based contrast agents in medicine and the environment

Clases, David; Sperling, Michael; Kärst, Uwe

doi:10.1016/j.trac.2017.12.011

Cited by 29 publications

(23 citation statements)

References 123 publications

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“…Since the first generation of an image using nuclear magnetic resonance in 1973, non-invasive diagnostic techniques, such as MRI, have been developed as an indispensable method in modern medicine. Although contrast agents are not necessary for MRI exams, 0.1 mmol of Gd per kg of body weight (average body weight is 70 kg [95]) has been applied in about 40% of MRI exams [96,97]. In comparison with other paramagnetic elements, such as manganese, dysprosium, iron, and copper, the paramagnetic characteristics of Gd 3+ are unparalleled [98].…”

Section: Gd-cas In Mrimentioning

confidence: 99%

“…Regarding the chelate type and charge, Gd-CAs can be divided into linear/macrocyclic and ionic/non-ionic groups. A wide range of Gd-CAs are commercially available and their stability is dependent on the conditional thermodynamic stability constant (K cond ), thermodynamic stability constant (K therm ), and kinetic stability ( Figure 3; Table 3) [97]. Higher values of K cond (at physiological pH tests) and K therm imply a greater Gd affinity for ligands, higher stability of Gd complexes, and less free gadolinium ion [102,103].…”

Section: Gd-cas In Mrimentioning

confidence: 99%

“…It is vital to monitor Gd species rather than the total Gd concentrations to further investigate the anomalous Gd anth and obtain more information about the processes and mechanisms resulting in Gd retention in organisms [97]. However, it is extremely challenging and likely impossible due to their low concentrations.…”

Section: Speciation Of Gd-casmentioning

confidence: 99%

“…Previously, Xia et al [196] assumed that a disrupted blood-brain barrier (BBB) leads to Gd plaques in brain tumors originating from Gd-CAs. Nonetheless, brain Gd accumulation is not limited to those with either a damaged BBB or renal dysfunction [97,197]. Kanda et al [198,199] found an association between high signal intensity in the brain of patients and frequent Gd-enhanced MRI applications in the past, irrespective of renal dysfunction.…”

Section: Human Health Risks Of Gd Anthmentioning

confidence: 99%

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Gadolinium as an Emerging Microcontaminant in Water Resources: Threats and Opportunities

Ebrahimi

Barbieri

2019

Geosciences

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As a result of high doses of paramagnetic gadolinium (Gd) chelates administered in magnetic resonance imaging (MRI) exams, their unmetabolized excretion, and insufficient removal in wastewater treatment plants (WWTPs), large amounts of anthropogenic Gd (Gdanth) are released into surface water. The upward trend of gadolinium-based contrast agent (Gd-CA) administrations is expected to continue growing and consequently higher and higher anthropogenic Gd concentrations are annually recorded in water resources, which can pose a great threat to aquatic organisms and human beings. In addition, the feasibility of Gd retention in patients administered with Gd-CAs repeatedly, and even potentially fatal diseases, including nephrogenic systemic fibrosis (NSF), due to trace amounts of Gd have recently arisen severe health concerns. Thus, there is a need to investigate probable adverse health effects of currently marketed Gd-CAs meticulously and to modify the actual approach in using Gd contrast media in daily practice in order to minimize unknown possible health risks. Furthermore, the employment of enhanced wastewater treatment processes that are capable of removing the stable contrast agents, and the evaluation of the ecotoxicity of Gd chelates and human exposure to these emerging contaminants through dermal and ingestion pathways deserve more attention. On the other hand, point source releases of anthropogenic Gd into the aquatic environment presents the opportunity to assess surface water—groundwater interactions and trace the fate of wastewater plume as a proxy for the potential presence of other microcontaminants associated with treated wastewater in freshwater and marine systems.

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Section: Gd-cas In Mrimentioning

confidence: 99%

Section: Gd-cas In Mrimentioning

confidence: 99%

Section: Speciation Of Gd-casmentioning

confidence: 99%

Section: Human Health Risks Of Gd Anthmentioning

confidence: 99%

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Gadolinium as an Emerging Microcontaminant in Water Resources: Threats and Opportunities

Ebrahimi

Barbieri

2019

Geosciences

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“…These concentrations may cause the appearance of severe diseases, such as nephrogenic systemic fibrosis (NSF) as well as accumulation in patients' brain, bones and kidneys (Idee et al, 2006). Pathological effects have been documented through histological examination, particularly regarding diffuse ulcerative calcific atherosclerosis, patchy myocardial necrosis and fibrosis, central venous congestion of the liver as well as calciphylaxis and necrotic skin (Clases et al, 2018). For patients with a median age of 55 years, an average time of 112 days between the diagnosis of NSF and death have been reported (Clases et al, 2018).…”

Section: Chelates Of Gadolinium As Contrast Agents In Magnetic Resonance Imagingmentioning

confidence: 99%

What do we know about the ecotoxicological implications of the rare earth element gadolinium in aquatic ecosystems?

Trapasso

Chiesa

Freitas

et al. 2021

Science of The Total Environment

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More research on gadolinium (Gd) occurrence in freshwater than marine environments • Few publications on the accumulation and effects of Gd in aquatic invertebrates • Higher diversity of freshwater species than marine species in Gd impacts studies. • Aquatic invertebrates differently bioaccumulate Gd according to its speciation. • Gd causes alterations at different biological levels in aquatic invertebrates.

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Single‐Cell Quantification of a Highly Biocompatible Dinuclear Iridium(III) Complex for Photocatalytic Cancer Therapy

et al. 2022

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Quantifying the content of metal-based anticancer drugs within single cancer cells remains a challenge. Here, we used single-cell inductively coupled plasma mass spectrometry to study the uptake and retention of mononuclear (Ir1) and dinuclear (Ir2) Ir III photoredox catalysts. This method allowed rapid and precise quantification of the drug in individual cancer cells. Importantly, Ir2 showed a significant synergism but not an additive effect for NAD(P)H photocatalytic oxidation. The lysosome-targeting Ir2 showed low dark toxicity in vitro and in vivo. Ir2 exhibited high photocatalytic therapeutic efficiency at 525 nm with an excellent photo-index in vitro and in tumor-bearing mice model. Interestingly, the photocatalytic anticancer profile of the dinuclear Ir2 was much better than the mononuclear Ir1, indicating for the first time that dinuclear metal-based photocatalysts can be applied for photocatalytic anticancer treatment.

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Analysis of metal-based contrast agents in medicine and the environment

Cited by 29 publications

References 123 publications

Gadolinium as an Emerging Microcontaminant in Water Resources: Threats and Opportunities

Gadolinium as an Emerging Microcontaminant in Water Resources: Threats and Opportunities

What do we know about the ecotoxicological implications of the rare earth element gadolinium in aquatic ecosystems?

Single‐Cell Quantification of a Highly Biocompatible Dinuclear Iridium(III) Complex for Photocatalytic Cancer Therapy

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