Analysis of metabolomics profile in hypothyroid patients before and after thyroid hormone replacement

Piras, Cristina; Pibiri, Monica; Leoni, Vera P.; Balsamo, Antonella; Tronci, Laura; Arisci, N; Mariotti, Stefano; Atzori, Luigi

doi:10.1007/s40618-020-01434-y

Cited by 26 publications

(26 citation statements)

References 47 publications

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“…Therefore, MYO exerts a crucial role in thyroid physiology, by its function in TSH regulation of iodination and by an increased sensitivity of thyrocytes to TSH. Metabolomic investigations confirmed such evidence, indicating that MYO demand is higher in hypothyroid patients than in healthy subjects ( 6 ), making MYO very appealing as a molecule to increase iodine availability counteracting thyroid dysfunctions ( 7 ).…”

Section: Myo-inositolmentioning

confidence: 92%

“…Myo-inositol (MYO), which is an isoform of inositol, has been shown to play an important role in thyroid physiology. Clinical evidence indicated that patients with impaired thyroid functionality exhibit a higher demand of MYO than healthy subjects ( 6 ). MYO altered levels or impaired inositol dependent TSH signaling pathway, may predispose to the development of some alterations in thyroid functionality, such as hypothyroidism, pointing out MYO crucial role in preserving thyroid physiology, in increasing iodine availability and in counteracting its dysfunctions ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management

et al. 2021

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Myo-Inositol (MYO) is the most abundant stereoisomer of inositols’ family, cyclic polyols with 6 hydroxyl groups. Myo-Inositol has a relevant role in thyroid function and autoimmune diseases, as a precursor of phosphoinositides that takes part in the phosphatidylinositol (PI) signal transduction pathway. Among phosphoinositides, phosphatidylinositol 4,5- bisphosphate (PIP2) is the precursor of inositol triphosphates (IP3), second messenger of several hormones including thyroid-stimulating hormone (TSH). As a second messenger in the phospholipase C (PLC)-dependent inositol phosphate Ca2+/DAG pathway, Myo-Inositol is essential to produce H2O2 required for the synthesis of thyroid hormones. Consequently, depletion of Myo-Inositol or impaired inositol dependent TSH signaling pathway may predispose to the development of some thyroid diseases, such as hypothyroidism. Many clinical studies have shown that after treatment with Myo-Inositol plus Selenium (MYO+Se), TSH levels significantly decreased in patients with subclinical hypothyroidism with or without autoimmune thyroiditis. The TSH reduction was accompanied by a decline of antithyroid autoantibodies. Moreover, Myo-Inositol supplementation seemed to be involved also in the management of thyroidal benign nodules, with a possible effect in the size reduction. This review proposes a summary of the role of inositol, especially of Myo-Inositol, in the thyroidal physiology and its contribution on the management of some thyroid diseases.

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Section: Myo-inositolmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management

et al. 2021

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“…Thyroid cells release oxidases, which catalyse ROS production [42][43][44]. Inositols are also involved in thyroid hormone synthesis and normal thyroid function, activating a cascade of processes including regulating TSH-dependent signalling (as a TSH transmitter) and generating H 2 O 2 production used for iodination and coupling of iodotyrosine and iodothyronine [45][46][47][48]. Inositol deficiency or impairment of inositol cascades may result in insufficient synthesis of thyroid hormones, leading to hypothyroidism, which may be further compounded by an increased need for inositols in response to high TSH levels [45,48].…”

Section: Physiological Redox Signalling and The Role Of Ros In Thyroid Functionmentioning

confidence: 99%

The Influence of Oxidative Stress on Thyroid Diseases

et al. 2021

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Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are becoming a serious social problem with rapidly increasing prevalence. The latter is increasingly linked to oxidative stress. There are many methods for determining the biomarkers of oxidative stress, making it possible to evaluate the oxidative profile in patients with thyroid diseases compared to the healthy population. This opens up a new perspective for investigating the role of elevated parameters of oxidative stress and damage in people with thyroid diseases, especially of neoplastic nature. An imbalance between oxidants and antioxidants is observed at different stages and in different types of thyroid diseases. The organ, which is part of the endocrine system, uses free radicals (reactive oxygen species, ROS) to produce hormones. Thyroid cells release enzymes that catalyse ROS generation; therefore, a key role is played by the internal defence system and non-enzymatic antioxidants that counteract excess ROS not utilised to produce thyroid hormones, acting as a buffer to neutralise free radicals and ensure whole-body homeostasis. An excess of free radicals causes structural cell damage, undermining genomic stability. Looking at the negative effects of ROS accumulation, oxidative stress appears to be implicated in both the initiation and progression of carcinogenesis. The aim of this review is to investigate the oxidation background of thyroid diseases and to summarise the links between redox imbalance and thyroid dysfunction and disease.

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“…The latter are influenced by several factors, such as (i) the TH blood transporters and membrane carriers, (ii) the interaction of extracellular TH with membrane receptors, (iii) the tissue-specific and cell type-specific expression of distinct DIO, (iv) the tissue-specific and cell type-specific expression and/or activity of distinct TRs isoforms, and (v) the clinical relevance of the derivative metabolites of TH [ 131 ]. Accurate assessment of intratissue and intracellular TH status can be achieved via exploration of the metabolome signature of TH status [ 132 , 133 ].…”

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

The Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research

Deligiorgi

Trafalis

2021

IJMS

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Exemplifying the long-pursued thyroid hormones (TH)–cancer association, the TH–lung cancer association is a compelling, yet elusive, issue. The present narrative review provides background knowledge on the molecular aspects of TH actions, with focus on the contribution of TH to hallmarks of cancer. Then, it provides a comprehensive overview of data pertinent to the TH–lung cancer association garnered over the last three decades and identifies obstacles that need to be overcome to enable harnessing this association in the clinical setting. TH contribute to all hallmarks of cancer through integration of diverse actions, currently classified according to molecular background. Despite the increasingly recognized implication of TH in lung cancer, three pending queries need to be resolved to empower a tailored approach: (1) How to stratify patients with TH-sensitive lung tumors? (2) How is determined whether TH promote or inhibit lung cancer progression? (3) How to mimic the antitumor and/or abrogate the tumor-promoting TH actions in lung cancer? To address these queries, research should prioritize the elucidation of the crosstalk between TH signaling and oncogenic signaling implicated in lung cancer initiation and progression, and the development of efficient, safe, and feasible strategies leveraging this crosstalk in therapeutics.

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Analysis of metabolomics profile in hypothyroid patients before and after thyroid hormone replacement

Cited by 26 publications

References 47 publications

The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management

The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management

The Influence of Oxidative Stress on Thyroid Diseases

The Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research

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