Analysis of memory modulation by conditioned stimuli

Lapointe, Thomas; Wolter, Michael; Leri, Francesco

doi:10.1101/lm.052407.120

Cited by 7 publications

(3 citation statements)

References 84 publications

(112 reference statements)

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“…Perhaps, this key difference between self-administered and yoked heroin was observed because drugs administered passively can produce aversive effects 37 . This is a possibility as aversive stimuli, including precipitated morphine withdrawal, can enhance consolidation of object recognition memory 38 , 39 . However, Study 1 demonstrated that 0.3 and 1 mg/kg heroin passively administered in the same operant chambers enhanced memory at 72 h (Fig.…”

Section: Discussionmentioning

confidence: 99%

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

Francis

Wolter

Leri

2022

Sci Rep

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Mode of administration (i.e., active vs passive) could influence the modulatory action that drugs of abuse exert on memory consolidation. Similarly, drug conditioned stimuli modulate memory consolidation and, therefore, acquisition and extinction of this conditioned response could also be influenced by mode of drug administration. Exploring these questions in male Sprague–Dawley rats, Study 1 assessed memory modulation by post-training 0, 0.3 and 1 mg/kg heroin injected subcutaneously in operant chambers (i.e., drug conditioned context). Study 2 asked a similar question but in rats trained to self-administer 0.05 mg/kg/infusion heroin intravenously, as well as in rats that received identical amounts of intravenous heroin but passively, using a yoked design. The period of heroin exposure was followed by repeated drug-free confinement in the conditioned context, and by sessions during which responses on the active lever had no scheduled consequences. Study 2 also included a cue-induced reinstatement session during which lever responses reactivated a light cue previously paired with intravenous heroin infusions. The post-training effects of injected/self-administered/yoked heroin, extinction and reinstatement sessions on memory consolidation were tested using the object location memory task. It was found that post-sample heroin enhanced memory in injected and yoked, but not self-administering, rats. However, post-sample exposure to the heroin cues (i.e., context or/and light cue) modulated memory equally in all groups. Taken together, these data support the conclusion that mode of administration impacts the cognitive consequences of exposure to drugs but not of environmental stimuli linked to their reinforcing effects.

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Section: Discussionmentioning

confidence: 99%

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

Francis

Wolter

Leri

2022

Sci Rep

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“…Viewed from the perspective of threat imminence theory [6][7][8][9] , this change in US density transforms the shock from a certain/imminent threat during initial acquisition to a possible/distal threat once the subject reaches asymptotic levels of SAA expression. Indeed, the CS will evoke high-imminence defensive reactions early in SAA training (freezing, ultrasonic vocalization, conditioned suppression, and conditioned analgesia), but these responses reduce as the expression of avoidance becomes more robust [10][11][12][13][14][15] . Despite evidence for a shift away from the defensive mode evoked by imminent threat, no previous research has explored the role played by the neural substrates of possible/distal threat in SAA.…”

Section: Introductionmentioning

confidence: 99%

The bed nucleus of the stria terminalis mediates the expression of proactive defensive behavior

Guerra

Wang

Souza

et al. 2022

Preprint

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The bed nucleus of the stria terminalis (BNST) is a forebrain region implicated in aversive responses to uncertain threat. Much of the work on the role of BNST in defensive behavior has used Pavlovian paradigms in which the subject reacts to aversive stimuli delivered in a pattern determined entirely by the experimenter. Here, we report that BNST also mediates proactive defensive responses in a task that allows subjects to prevent the delivery of an aversive outcome. In a standard two-way signaled active avoidance paradigm, male rats learned to shuttle during a tone to avoid shock. Our data demonstrate that chemogenetic inhibition (hM4Di) of BNST attenuates the expression of the avoidance response, whereas chemogenetic activation (hM3Dq) of BNST potentiates the response by extending the period of tone-evoked shuttling. This effect was specific to the BNST, as inactivation of the neighboring medial septum produced no effect on the expression of avoidance. These data support the novel conclusion that BNST mediates two-way avoidance behavior in male rats.

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“…For example, using the spontaneous object recognition memory task, it has been found that drug-free rats exposed immediately post-training to a heroin-paired CS displayed enhanced object memory when tested 72 h later [9,10] . Others have observed similar effects with CSs paired with foot-shock or sucrose in different memory tasks [12,13] .…”

Section: Introductionmentioning

confidence: 71%

The effects of active and passive intravenous heroin and heroin conditioned stimuli on consolidation of object memory

Francis

Wolter

Leri

2022

Preprint

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Drugs of abuse and their associated conditioned stimuli (CS) modulate memory consolidation, but it is possible that these effects are influenced by the mode of administration (i.e., active vs passive). This study employed a self-administration/yoked design in male Sprague-Dawley rats (N = 36): one group (n = 18) intravenously self-administered infusions of 0.05 mg/kg heroin paired with the activation of a light CS, and a yoked group (n = 18) received an equal number of infusions and light CS presentations independent of their lever responses. Self-administration/yoked training was followed by extinction during which responses on the active lever had no consequences, and by a cue-induced reinstatement session during which active lever responses resulted in the reactivation of the light CS, but no heroin delivery. The post-training effects of self-administered/yoked heroin, extinction and reinstatement sessions on memory consolidation were tested using the object location memory task. It was found that post-sample heroin enhanced object location memory in yoked, but not self-administering rats. However, post-sample extinction and reinstatement sessions equally modulated memory in both groups. Taken together, these data in rats support the perspective that mode of administration impacts the cognitive consequences of exposure to drugs and environmental stimuli linked to their reinforcing effects.

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Analysis of memory modulation by conditioned stimuli

Cited by 7 publications

References 84 publications

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

The bed nucleus of the stria terminalis mediates the expression of proactive defensive behavior

The effects of active and passive intravenous heroin and heroin conditioned stimuli on consolidation of object memory

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