Analysis of Megavariate Data in Functional Omics

Abstract

This article was originally published in Comprehensive Chemometrics, 2nd edition, published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non-commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who you know, and providing a copy to your institution's administrator.

Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients

“…Microbiota microorganisms present in a defined environment [46] Metagenome the collection of genomes and genes sequenced from members of a microbiota [46] Microbiome the entire habitat, including the microorganisms, their genomes, and the surrounding environmental conditions [46] Metabolome collection of all metabolites present in the cell that are participants in general metabolic reactions [47] Omics large-scale study of data representing an entire set of molecules, such as proteins, lipids, or metabolites, in a cell, organ, or organism Multiomics an approach that examines multiple omics data sets such as genomics, proteomics, transcriptomics, metabolomics, and microbiomics…”

Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules for cancer research

“…The omics cascade describes the hierarchical flow of information through biological systems, 1 beginning from the genome (DNA), the information is passed over the transcriptome (mRNA) down to specific protein species, called proteoforms. 2 The proteoforms are then effecting the organism's metabolism and lead to the production of metabolites, which are required for a cell's normal function, growth and maintenance 3 and can be subdivided into sugars, nucleotides, amino acids, lipids and others. 4 To fully understand tissue and the characteristics of diseases, it is essential to study tissue on the molecular level in terms of the omics cascade utilizing multi-omics techniques, such as genomics, transcriptomics, proteomics and metabolomics, while preserving the spatial information from the tissue microenvironment.…”