Analysis of matrix metalloproteinase-7 expression in eutopic and ectopic endometrium samples from patients with different forms of endometriosis

Abstract

These findings suggest that MMP-7 expression levels vary significantly among the different forms of endometriosis.

The role of metalloproteinases in endometrial remodelling during menstrual cycle

“…It has been demonstrated that progesterone treatment can suppress directly or indirectly the MMP-7 gene and protein expression [30]. MMP-7 may also play a role in the pathogenesis of endometriosis since MMP-7 expression levels in the endometrial epithelial cells of patients with deep infiltrating endometriosis are significantly higher compared to less severe disease [31]. Cervical cancer cells are capable of producing large quantities of MMP-7 [26].…”

Endometriosis research using capture microdissection techniques: Progress and future applications

“…Twelve studies that used LCM identified endometriosis-related differentially expressed genes (DEGs) (43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54). According to their biological functions, positive DEGs can be assigned to the following categories: Proliferation and apoptosis, pain pathway, hormones and steroids, adhesion and implantation, and DNA methylation, with parts of the gene functions overlapping (Table IV).…”

“…Matrix metalloproteinase-7 (MMP-7), a member of the MMP family, cleaves extracellular matrix components in normal physiological and pathological processes. A study revealed that the expression levels of MMP-7 in DIE were significantly higher than those in ovarian and superficial peritoneal types (54). Thus, the MMP-7 gene appears to significantly vary among different types of endometriosis and represents a useful marker for discriminating between them.…”

Endometriosis and Angiogenic Factors

“…In addition, a recent study clearly demonstrated that MMP-7 mRNA was identified in host peritoneal tissues during the development of endometriosis in a nude mouse model MMP-7 protein expression in epithelial cells was significantly higher in red peritoneal lesions compared with that of deep infiltrating endometriosis, ovarian endometriosis and black peritoneal lesions, in all phases of the menstrual cycle. MMP-7 protein expression may be down-regulated during the evolution of peritoneal endometriotic implants, as active red lesions transition into inactive black lesions (Matsuzaki et al, 2010).…”