Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population

Lee, Seong-Gene; Yum, Jung-Sun; Moon, Heehyul; Kim, Hyun Jung; Yang, Yunju; Kim, Hie-Lim; Yoon, Yongsook; Lee, Sun Young; Song, Kyuyoung

doi:10.1016/j.molimm.2004.09.036

Cited by 57 publications

(57 citation statements)

References 26 publications

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“…Mannose-binding lectin and its genetic variants P Garred et al recently become clear that MBL obtained from different genotypes may be present in larger amounts than previously anticipated and that they represent different oligomerization patterns in serum 32,[50][51][52][53] ( Figure 3 and 6). Variant MBL binds bacteria and mannan with lower avidity than normal MBL without activating the complement system.…”

Section: Consequences Of Mbl2 Gene Variations On Mbl Serum Levelsmentioning

confidence: 92%

Mannose-binding lectin and its genetic variants

et al. 2006

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Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of importance for host defence. Common variant alleles situated both in the promoter and structural region of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variation in MBL serum concentration influences the susceptibility to and the course of different types of infections, autoimmune, metabolic and cardiovascular diseases, but this is still a subject of debate. The fact that these genetic variations are very frequent indicates a dual role for MBL in host defence. In this survey, we summarize the current molecular understanding of human MBL genetics.

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Section: Consequences Of Mbl2 Gene Variations On Mbl Serum Levelsmentioning

confidence: 92%

Mannose-binding lectin and its genetic variants

et al. 2006

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“…There are also promoter polymorphisms recognised on the MBL2 gene which affects translocation of MBL (H/L or X/Y) but they generally cause minor reduction in levels compared with the A/O gene defects [18,22,26,27]. Studies show MBL levels to be fairly constant after childhood remaining stable throughout adulthood with no influence of gender [27].…”

Section: Introductionmentioning

confidence: 99%

The Deficiency of Serum Mannose Binding Lectin in Early Onset Idiopathic Pulmonary Fibrosis and Familial Cases

VA¹

2012

J Clin Cell Immunol

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“…12,13 In African, European, Asian and native American populations, the promoter haplotypes HYP and LYQ cause the highest and LXP the lowest MBL concentration in plasma [13][14][15][16][17][18][19] (see Table 1 for the official nomenclature of these and other MBL2 variants). Lower polymerization level and reduced plasma concentration of MBL multimers are associated with the variants B, C and D, which occur in the first exon of the gene.…”

Section: Introductionmentioning

confidence: 99%

Association of a new mannose-binding lectin variant with severe malaria in Gabonese children

et al. 2006

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Mannose-binding lectin (MBL2) variants that decrease the plasma level of the protein or encode dysfunctional proteins are frequently associated with the severity of a number of infections and autoimmune disorders. The high frequencies of these variants in most populations of the world are probably maintained by some selective advantage against widespread diseases. We found 14 new MBL2 allelic haplotypes, two of them with non-synonymous variants, by screening 136 children with uncomplicated malaria, 131 children with severe malaria and 39 older healthy schoolchildren. We also found a significant association of a novel variant with susceptibility to severe malaria (P ¼ 0.010). Increased MBL plasma levels and corresponding MBL2 genotypes were associated with lower concentration of several cytokines and chemokines in plasma of malaria patients. We suggest that malaria could have been one of the evolutionary driving forces shaping the MBL2 polymorphism in the African population.

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Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population

Cited by 57 publications

References 26 publications

Mannose-binding lectin and its genetic variants

Mannose-binding lectin and its genetic variants

The Deficiency of Serum Mannose Binding Lectin in Early Onset Idiopathic Pulmonary Fibrosis and Familial Cases

Association of a new mannose-binding lectin variant with severe malaria in Gabonese children

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