Analysis of major herbs in Chinese herbal formula Jianpi Huoxue Decoction for improving intestinal permeability based on uniform design

Fu, Qilin; Hu, Yiyang; Wang, Xiaoning; Peng, Jinghua; Cui, Tuan

doi:10.3736/jcim20111112

Cited by 4 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…How could we reorganize the new recipe? Our research team successfully launched several studies on Chinese herbal active components recipes by using the mathematical model of uniform design which was proposed by Fang [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLDIn VivoandIn Vitro

Meng

Liu

Tang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

This study is to investigate the therapeutic effects of the recipe composed of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide (named ACG) on experimental nonalcoholic fatty liver (NAFL). The research was divided into two parts as screening experiment and verification experiment. In the screening experiment, we used high-fat diet (HFD) induced NAFL rat model and uniform design to get the recipe from five Chinese herbal active components. In the verification experiment, HFD induced fatty liver rat and mouse NAFL models and free fatty acid (FFA) induced HepG2 cell model were used to verify the effects of ACG. According to the multiple regression equation of the hepatic triglyceride (TG) contents of each group in the screening experiment, the recipe ACG was obtained and the doses of Atractylodes macrocephala polysaccharide, chlorogenic acid, and geniposide for rats were 266.67, 3.33, and 45 mg/kg, respectively. The results of verification experiment verified that ACG could significantly reduce hepatic TG contents of NAFL rats and mice, as well as the cellular TG content of FFA-induced HepG2 cells. ACG could also improve HOMA-IR and hepatic mitochondrial ultrastructure of NAFL mice. Our study verified that ACG recipe could regulate lipid metabolism of NAFL in vivo and in vitro.

show abstract

Section: Discussionmentioning

confidence: 99%

A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLDIn VivoandIn Vitro

Meng

Liu

Tang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Alismatis Rhizoma has been found to exert the effect of hypoglycemic activities and metabolism combined with other herbal medicines [19,20].…”

Section: Other Pharmacological Activitiesmentioning

confidence: 99%

Alisma orientalis (Sam.) Juzep. 泽泻 (Zexie, Alismatis Rhizoma)

Wang

2015

Dietary Chinese Herbs

View full text Add to dashboard Cite

Chinese medicine formula “Weikang Keli” induces autophagic cell death on human gastric cancer cell line SGC-7901

et al. 2013

View full text Add to dashboard Cite

Analysis of major herbs in Chinese herbal formula Jianpi Huoxue Decoction for improving intestinal permeability based on uniform design

Abstract: Baishao, Zexie and Wuweizi are the major herbs of Jianpi Huoxue Decoction for improving intestinal permeability. Uniform design is efficient in screening the major herbs or their optimal combination in a certain Chinese compound.

Cited by 4 publications

References 3 publications

A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLDIn VivoandIn Vitro

A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLDIn VivoandIn Vitro

Alisma orientalis (Sam.) Juzep. 泽泻 (Zexie, Alismatis Rhizoma)

Chinese medicine formula “Weikang Keli” induces autophagic cell death on human gastric cancer cell line SGC-7901

Contact Info

Product

Resources

About