Analysis of macular curvature in normal eyes using swept-source optical coherence tomography

Minami, S.; Ito, Yasuki; Ueno, Shinji; Kataoka, Keiko; Takeuchi, Jun; Ito, Hirotaka; Nakano, Yuyako; Kitagawa, Masahiro; Leahy, Conor; Straub, Jochen; Terasaki, Hiroko

doi:10.1007/s10384-020-00721-8

Cited by 10 publications

(15 citation statements)

References 25 publications

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“…compared eyes with emmetropia to those with myopia using MRI, and found that the prolate shape was associated with high myopia, while the spherical shape may constitute a biomechanical limitation to further axial elongation. Sou et al 17 . also reported similar results regarding the curvature of the RPE and CSI and axial length, revealing that the difference between the curvatures was associated with choroidal thickness.…”

Section: Discussionmentioning

confidence: 63%

“…Sou et al 17 . reported the clinical significance of the difference between the RPE and CSI contours in normal adult eyes.…”

Section: Resultsmentioning

confidence: 99%

“…The thickness of the subfoveal choroid was defined as the distance from the outer surface of the RPE to the inner surface of the chorioscleral interface (CSI) of the fovea ( Figure ) 22 . The contours of the RPE and CSI, which were evaluated to describe the posterior ocular contour, were used for the analysis 17 …”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, existing studies based on OCT analyses have not successfully clarified the relationship between the posterior ocular structure and the early progression of myopia since participants were adults with high myopia, and thus the progression of myopia could not be evaluated 1,15 . Some cross‐sectional studies have offered reliable methods for analysing and determining the contour of the posterior eye 16,17 . However, whether certain posterior eye structures influence subsequent myopia progression remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Association between the posterior ocular contour pattern and progression of myopia in children: A prospective study based on OCT imaging

Cui

et al. 2021

Ophthalmic Physiologic Optic

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Purpose This study aims to reveal the relationship between the posterior ocular contour and the subsequent progression of myopia in children. Methods Children aged 8–12 years with myopia received baseline measurements and were instructed to wear their glasses every day and return for a follow‐up visit after one year. Axial length and other ocular parameters were measured using a noncontact biometer. The contour of the posterior eye was calculated and analysed based on images from spectral domain optical coherence tomography (SD‐OCT). Univariate and multivariate linear regression models were created to analyse the relationship between the contour of the posterior eye and the progression of myopia. Results Baseline posterior ocular contour measurements correlated with baseline axial length and spherical equivalent refraction (SER) (all p < 0.05). Eyes that were more myopic tended to have a more prolate posterior ocular contour. Although the baseline contour of the retinal pigment epithelium (RPE) and chorioscleral interface (CSI) showed no significant relationship with the progression of myopia (all p > 0.05), interestingly, when the baseline contour of the RPE was more prolate than that of the CSI, the axial length increased during the following year (R2 = 0.62; p < 0.01). The multivariate model, when adjusted for other variables, further validated the independent role of this variable. Conclusions The difference between the RPE and CSI contours correlated with the subsequent progression of myopia in children. This finding can help inform clinicians regarding the management of children at the onset of myopia and potentially provide an avenue for experimental research on the mechanism of myopia development.

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Section: Discussionmentioning

confidence: 63%

“…Sou et al 17 . reported the clinical significance of the difference between the RPE and CSI contours in normal adult eyes.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between the posterior ocular contour pattern and progression of myopia in children: A prospective study based on OCT imaging

Cui

et al. 2021

Ophthalmic Physiologic Optic

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“…Previous researches recorded a high relationship existed between myopia and CT in children and adults. These studies have documented that thinner CT was found in high myopic eyes than in normal eyes [8] . But these studies did not correlate other factors such as AL [9] .…”

Section: Discussionmentioning

confidence: 92%

Choroidal thickness in different degrees of myopia measured by enhanced depth imaging mode optical coherence tomography

Abd-Elkhalek

Abdelrahman

Aly

et al. 2022

International Journal of Medical Arts

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Article information Background: Choroidal thickness [CT] is associated with many ocular conditions. Different generations of optical coherence tomography [OCT] are important for clinical application. Objective: This study aimed to evaluate the effect of myopia on CT by the use of enhanced depth imaging [EDI] OCT and correlate the measured data with both the axial length [AL] and the refraction. Patients and Methods: A Cross-sectional study included 80 adult patients of both sexes. The patients were divided into 4 groups: [G1, control]: 20 emmetropic subjects. [G2]: 20 myopic patients with refraction up to -6 D. [G3]: 20 myopic patients with refraction >-6 D up to -10 D and [G4]: 20 myopic patients with refraction > -10 D.Spectralis OCT has been utilized in assessing CT in subfoveal region, 500, 1000 and 1500 um temporal and nasal to fovea. Results: A highly statistically significant variation existed among groups considering AL and refraction with G4 having higher values and G2 and G1 having lower values. Regarding CT, the highest value was found in G1 and 2, followed by G3, but the lowest value was found in G4. There was significant positive correlation between refraction in all patients and their AL [p< 0.001], and significant negative correlation appeared between refraction and AL in all patients regarding their all measures of CT [nasal, temporal and subfoveal] [p < 0.001]. Conclusion: Myopia with different degrees caused a decrease in CT compared to its thickness of healthy eyes, with marked thinning in advanced myopia.

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Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Wu,

Liu,

Liu

et al. 2024

Ophthalmol Ther

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Introduction To evaluate the intraocular differences in optical coherence tomography (OCT)-based macular curvature index (MCI) among children with anisomyopia and to investigate the relationship between MCI and the macular microvasculature. Methods Fifty-two schoolchildren with anisometropia > 2.00 D were enrolled and underwent comprehensive examinations including cycloplegic refraction, axial length (AL), and swept source OCT/OCT angiography. OCT-based MCIs were determined from horizontal and vertical B-scans by a customized curve fitting model in MATLAB R2022 at 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea. Characteristics and topographic variation of MCI was analyzed, and the relationships with microvascularity and its associated factors were investigated. Results MCI achieved high reliability and repeatability. There were overall larger MCIs in the more myopic eyes than the less myopic eyes in 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea (all p < 0.001). For the topographic variation, horizontal MCI was significantly greater than vertical MCI (all p < 0.001), and was the largest in 6-mm circle, followed by 3-mm and 1-mm circles. Stronger correlation of horizontal MCI with myopic severity than vertical MCI was found. Partial Pearson’s correlation found MCI was negatively associated with deep capillary plexus (DCP) vessel density ( p = 0.016). Eyes with a higher MCI in a 6-mm circle were more likely to have longer AL ( p < 0.001), lower DCP vessel density ( p = 0.037), and thinner choroidal thickness (ChT) ( p = 0.045). Conclusion Larger MCI was found in the more myopic eyes of children with anisomyopia and was significantly associated with smaller DCP density, suggesting that MCI was an important indicator of myopia-related retinal microvascularity change, and it could be a valuable metric for myopia assessment in children. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-024-00956-5.

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Analysis of macular curvature in normal eyes using swept-source optical coherence tomography

Cited by 10 publications

References 25 publications

Association between the posterior ocular contour pattern and progression of myopia in children: A prospective study based on OCT imaging

Association between the posterior ocular contour pattern and progression of myopia in children: A prospective study based on OCT imaging

Choroidal thickness in different degrees of myopia measured by enhanced depth imaging mode optical coherence tomography

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

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