Analysis of Macular and Peripapillary Choroidal Thickness in Glaucoma Patients by Enhanced Depth Imaging Optical Coherence Tomography

Park, Hae-Young Lopilly; Na-young, Lee; Shin, Haeyoung; Park, Chan Kee

doi:10.1097/ijg.0000000000000045

Cited by 70 publications

(92 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although Park et al 29 have not observed significant differences in peripapillary and macular choroidal thickness in patients with POAG when compared with controls, they have detected a significant decrease in peripapillary choroidal thickness in patients with NTG when compared with controls. In our study, we did not find any difference in macular choroidal thickness in the PXS group when compared with the control group after adjusting for age and axial length.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Moghimi

Mazloumi

Johari

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Moghimi S, Mazloumi M, Johari MK, et al. Evaluation of lamina cribrosa and choroid in nonglaucomatous patients with pseudoexfoliation syndrome using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2016;57:129357: -130057: . DOI:10.1167 PURPOSE. To evaluate the lamina cribrosa (LC) and peripapillary choroid in patients with pseudoexfoliation syndrome (PXS). METHODS.In this cross-sectional study, one eye each of 32 nonglaucomatous PXS cases and 29 healthy volunteers were enrolled. The optic discs were scanned using enhanced depth imaging spectral-domain optical coherence tomography, and measurements were obtained using HEYEX software 6.0. LC and other related variables at three areas (mid-superior, center, and mid-inferior) and peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust the variables. RESULTS.After adjustment for age, sex, and axial length, there was no significant difference between the two groups in peripapillary choroidal thickness or in retinal nerve fiber layer thickness. The LC was significantly thinner in all three areas in the PXS group when compared with the control group, even after adjustment. Although no significant difference in central laminar depth was observed between the two groups (P ¼ 0.74), the superior and inferior laminar depth were significantly deeper in the PXS group when compared with the control group (P ¼ 0.04 and P ¼ 0.006, respectively). Although there was a significant negative association between age and central choroidal thickness in the control group (b ¼ À2.820, P ¼ 0.02), this correlation was not significant in the PXS group.CONCLUSIONS. We found that LC is significantly thinner in all three areas of the optic nerve head in nonglaucomatous PXS patients than in controls. Although no significant difference in peripapillary choroidal thickness was observed between the two groups, peripheral posterior displacement of LC in nonglaucomatous PXS eyes was noted.

show abstract

Section: Discussionmentioning

confidence: 90%

“…[28][29][30][31] The choroid may exert its effects via its nutritional and vascular support of the ONH.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Moghimi

Mazloumi

Johari

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Gharbiya et al (2014) have reported significant thinning of the choroid. The main disadvantage is that inability of choroidal OCT to distinguish AD from other diseases like glaucoma (Alonso Canerio et al 2013;Park et al 2014;Zhang et al 2014). Whether the patients with mild cognitive impairment and retinal thinning have a higher incidence of conversion to AD is not still determined and studies are needed to address this question (Winblad et al 2004).…”

Section: Results Of Review Of Systematic Evidencementioning

confidence: 99%

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

Mahajan

Votruba

2017

Acta Ophthalmologica

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of senile dementia. It impairs the quality of life of a person and their family, posing a serious economic and social threat in developed countries. The fact that the diagnosis can only be definitively made post‐mortem, or when the disease is fairly advanced, presents a serious problem if novel therapeutic interventions are to be devised and used early in the course of the disease. There is therefore a pressing need for more sensitive and specific diagnostic tests with which we can detect AD in the preclinical stage. The tau proteins and beta‐amyloid proteins start to accumulate 20 years before the symptoms begin to manifest. Detecting them in the preclinical stage would be a potential breakthrough in the management of AD. A high degree of clinical suspicion is needed to correlate problems in cognition with the changes in the eye, particularly the retina, pupil and ocular movements, so that the disease can be detected early and managed in the prodromal phase. In this systematic review, we ask the question whether the retina can be used to make a specific and early diagnosis of AD.

show abstract

“…However, in their study, the average peripapillary choroidal thickness was significantly thinner in NTG (147.01 ± 35.31 μm) than in control (226.35 ± 39.52 μm, P<0.001) and high-pressure POAG (200.11 ± 32.16 μm, P<0.001) eyes. Significant differences in the peripapillary choroidal thickness were observed between high-pressure POAG and NTG eyes in early, moderate, and severe stages of glaucoma (P=0.017, P<0.001, and P<0.001, respectively), classified by the VF MD index (68) . Furthermore, a possible association between glaucoma and reduced choroidal thickness has been reported, but it is not yet clear whether it is primary or secondary to glaucoma damage.…”

Section: Choroidal Thicknessmentioning

confidence: 99%

Normal-tension glaucoma: an update

Esporcatte¹,

Tavares²

2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

However, several structural and functional differences support the fact that different mechanisms may have a stronger role in the pathogenesis of NTG versus high-pressure POAG. Also, a recent study reported genetic variants associated with different tendencies towards POAG with lower or higher IOP (6) . Furthermore, clinical impression and anecdotal evidence suggest that NTG with mean IOP in the high teens (>15 mmHg), in which circadian fluctuation and CCT could lead to a possible misdiagnosis of an IOP ≤21 mmHg, would differ from NTG with mean IOP in the low teens (≤15 mmHg), with different ABSTRACT Descritores: Glaucoma de ângulo aberto; Pressão in traocular; Doenças do nervo óptico; Anti-hipertensivos/uso terapêuticopathogenesis and progression patterns, harder to achieve target IOP, and higher incidence of disc hemorrhages. Nonetheless, a recent report does not support this assumption and underscores low-teens NTG as an important entity (7) . The proportion of NTG varies depending on different population studies. In Asian epidemiological protocols, NTG constituted the majority of open-angle glaucomas (52%-92%), depending on the country and study methodology (8) . Normal IOP was measured in 57.1% cases of POAG in a South African study (9) . In white populations, the proportion of NTG was lower than that observed in Asian and African populations. In studies conducted in the United States, Netherlands, and Italy, NTG presented proportions of 31. 7%, 38.9%, and 30%, respectively (10-12) . The etiology of NTG is most likely multifactorial and still not well defined. Moreover, several alternative treatments based on this different pathogenesis have been discussed. The objective of this study was to review the mechanisms involved in the onset and progression of NTG and the efficacy of established and alternative therapies for NTG treatment. PathogenesisThe pathogenesis of NTG is unclear, and perhaps the development of the disease is a consequence of a complex interaction of several systemic and ocular factors. Different studies have shown that the cardiovascular system and intracranial pressure may be involved in the main pathways of optic nerve damage. Nevertheless, the complex relationship between these mechanisms and glaucoma pro gression continues to be debated.

show abstract

Analysis of Macular and Peripapillary Choroidal Thickness in Glaucoma Patients by Enhanced Depth Imaging Optical Coherence Tomography

Abstract: Peripapillary choroidal thickness was significantly reduced in NTG eyes based on EDI OCT measurements in vivo.

Cited by 70 publications

References 8 publications

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

Normal-tension glaucoma: an update

Contact Info

Product

Resources

About