Analysis of macrophage subtypes and annexin A1 expression in lesions of patients with cutaneous leishmaniasis

Silva, Joselina Maria da; Silva, Helen Aguiar Lemes da; Zelenski, Carolina; Souza, Jéssica Azevedo de Moraes; Hueb, Márcia; Damazo, Amílcar Sabino

doi:10.1590/0037-8682-0361-2019

Cited by 7 publications

(16 citation statements)

References 26 publications

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“…Proteomic studies have shown that macrophage-derived EVs contain a large number of alarmins (one of endogenous molecules) (Figure 3). Annexins can stimulate bone resorption (Li et al, 2005), improve the phagocytic efficiency of macrophage (Stukes et al, 2016), which is related to Multiple myeloma (MM) (D'Souza et al, 2012) and play an auxiliary role of macrophages in infected tissues (Silva et al, 2019;McArthur et al, 2020;Sanches et al, 2020). Galectins mainly affect the differentiation of bone marrow stromal cells (Andersen et al, 2003), osteoblast, osteoclast (Shimura et al, 2005;Nakajima et al, 2014;Simon et al, 2017;Iacobini et al, 2018) and the osteogenesis of mesenchymal stem cells (Weilner et al, 2016).…”

Section: Macrophage-derived Exosomes (Vesicles) Regulate Bone Metabolismmentioning

confidence: 99%

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Chen

Jiao

Liu

et al. 2020

Front. Cell Dev. Biol.

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The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

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Section: Macrophage-derived Exosomes (Vesicles) Regulate Bone Metabolismmentioning

confidence: 99%

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Chen

Jiao

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…Other studies have reported similar results [14][15][16][17] . The infection caused by M. leprae induces a specific immune response that is directly associated with the clinical form existing in the individual [10][11][12][13][14][15] . Leukocyte recruitment to an inflammatory site is mainly triggered by a strong Th1 response, resulting in granuloma formation, predominantly formed by histiocytes and lymphocytes, in an attempt to eliminate the bacillus [21][22][23][24][25][26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

“…Other skin diseases, such as psoriasis vulgaris and keratosis follicularis, induce the expression of ANXA1 10 . ANXA1 is also upregulated in skin lesions of patients with leishmaniasis, especially in lymphocytes and macrophages 11,12 . Silva et al 12 showed that ANXA1 is highly expressed during exudative cellular reactions against Leishmania infection.…”

Section: Introductionmentioning

confidence: 99%

“…ANXA1 is also upregulated in skin lesions of patients with leishmaniasis, especially in lymphocytes and macrophages 11,12 . Silva et al 12 showed that ANXA1 is highly expressed during exudative cellular reactions against Leishmania infection. In contrast, in the granulomatous reaction, the expression was attenuated, and parasite elimination was more favorable.…”

Section: Introductionmentioning

confidence: 99%

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Expression of annexin-A1 in blood and tissue leukocytes of leprosy patients

Ribeiro

Caloi

Pimenta

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: In leprosy, immune system mediators that regulate the infectious process act in a complex manner and can lead to several clinical outcomes. To understand the behavior of these mediators we quantified the expression of annexin-A1 (ANXA1) in the peripheral blood and plasma as well as tissue leukocytes in all clinical forms of leprosy and compared with healthy controls. Methods: Seventy healthy controls and 70 patients with leprosy, tuberculoid (TT) (n = 13), borderline tuberculoid (BT) (n = 15), borderline borderline (BB) (n = 13), borderline lepromatous (BL) (n = 15), and lepromatous leprosy (LL) (n = 14), were selected. Phenotyping of the lymphocyte cells and the intracellular expression of ANXA1 in leukocytes was performed by immunofluorescence. Plasma protein levels were determined by enzyme-linked immunosorbent assay. Results: Histiocytes and CD4 + and CD8 + T cells in the skin of BL and LL patients had higher ANXA1 expression. ANXA1 expression was also high in circulating polymorphonuclear, monocytes, and CD4 + and CD8 + T cells in the blood of LL patients compared to those of TT, BT, BB, and BL patients, and these levels were similar to those in healthy controls. Plasma ANXA1 levels indicate an increase in paracrine release in patients with LL. Conclusions: The data indicate that ANXA1 expression is enhanced in the leukocytes and plasma of patients with LL, and may contribute to the inhibition of leukocyte action, leading to inadequate functioning of the immune system and thus contributing to the spread of M. leprae infection.

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“…Among them, the protein annexin A1 (ANXA1) can be emphasized as a potent endogenous modulator of inflammation 3,6,7 , leukocyte apoptosis 8 , and apoptotic cell clearance 9 . Although several studies have evaluated ANXA1 actions, only few have focused on the CL-related infectious processes 4,10 . The present study aimed to determine the number of macrophages and apoptotic cells in the skin lesions of patients with leishmaniasis and analyze ANXA1 detection in these cells.…”

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confidence: 99%

Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis

Pona

Dietrich

Silva

et al. 2021

Rev. Soc. Bras. Med. Trop.

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Analysis of macrophage subtypes and annexin A1 expression in lesions of patients with cutaneous leishmaniasis

Cited by 7 publications

References 26 publications

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Expression of annexin-A1 in blood and tissue leukocytes of leprosy patients

Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis

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