Analysis of Long Noncoding RNAs in Choroid Neovascularization

Zhang, Pengfei; Lu, Bing; Xu, Feng-Yuan; Wang, Chen; Zhang, Rongrong; Liu, Yinping; Wei, Chenghua; Mei, Lixin

doi:10.1080/02713683.2020.1748659

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…By the further analysis of four validated lncRNAs (ENSMUST00000165968, ENSMUST00000153785, ENSMUST00000134409, and ENSMUST00000154285) and the nearby coding gene, the authors concluded that the interacted mRNAs were mainly enriched in blood vessel development, angiogenesis, cell adhesion molecules, and leukocyte transendothelial migration pathways. The conclusions on the involvement of lncRNAs in the CNV were confirmed in another work with the use of essentially the same attitude and methods [98].…”

Section: Long Non-coding Rnas In Amd Modelsmentioning

confidence: 52%

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Błasiak

Hyttinen

Szczepańska

et al. 2021

IJMS

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Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with poorly known pathogenesis and lack of effective treatment. Age and family history are the strongest AMD risk factors, and several loci were identified to contribute to AMD. Recently, also the epigenetic profile was associated with AMD, and some long non-coding RNAs (lncRNAs) were shown to involve in AMD pathogenesis. The Vax2os1/2 (ventral anterior homeobox 2 opposite strand isoform 1) lncRNAs may modulate the balance between pro- and anti-angiogenic factors in the eye contributing to wet AMD. The stress-induced dedifferentiation of retinal pigment epithelium cells can be inhibited by the ZNF503-AS1 (zinc finger protein 503 antisense RNA 2) and LINC00167 lncRNAs. Overexpression of the PWRN2 (Prader-Willi region non-protein-coding RNA 2) lncRNA aggravated RPE cells apoptosis and mitochondrial impairment induced by oxidative stress. Several other lncRNAs were reported to exert protective or detrimental effects in AMD. However, many studies are limited to an association between lncRNA and AMD in patients or model systems with bioinformatics. Therefore, further works on lncRNAs in AMD are rational, and they should be enriched with mechanistic and clinical studies to validate conclusions obtained in high-throughput in vitro research.

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Section: Long Non-coding Rnas In Amd Modelsmentioning

confidence: 52%

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Błasiak

Hyttinen

Szczepańska

et al. 2021

IJMS

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“… 37 A previous study reported that H19 expression was significantly increased in patients with wet AMD and in a choroidal neovascularization mouse model, and inhibiting H19 can inhibit M2 macrophage gene expression in this mouse model. 38 In addition, H19 participates in the regulation of epidermal mesenchymal transition in diabetic retinopathy. 39 Therefore, lncRNA H19 might be closely related to the occurrence of RD.…”

Section: Discussionmentioning

confidence: 99%

RNA-seq analysis reveals differentially expressed inflammatory chemokines in a rat retinal degeneration model induced by sodium iodate

et al. 2022

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Objective Retinal degeneration (RD) is a group of serious blinding eye diseases characterized by photoreceptor cell apoptosis and progressive degeneration of retinal neurons. However, the underlying mechanism of its pathogenesis remains unclear. Methods In this study, retinal tissues from sodium iodate (NaIO3)-induced RD and control rats were collected for transcriptome analysis using RNA-sequencing (RNA-seq). Analysis of white blood cell-related parameters was conducted in patients with retinitis pigmentosa (RP) and age-related cataract (ARC) patients. Results In total, 334 mRNAs, 77 long non-coding RNAs (lncRNAs), and 20 other RNA types were identified as differentially expressed in the retinas of NaIO3-induced RD rats. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that differentially expressed mRNAs were mainly enriched in signaling pathways related to immune inflammation. Moreover, we found that the neutrophil-to-lymphocyte ratio was significantly higher in RP patients than in ARC patients. Conclusion Overall, this study suggests that multiple chemokines participating in systemic inflammation may contribute to RD pathogenesis.

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“…57,58 In particular, 128 lncRNAs able to target angiogenetic genes and 744 lncRNAs binding factors involved in inflammation and immunity pathways were reported to be altered in CNV mice models compared to controls. Moreover, H19 lncRNA has been found increased in vitreous humor collected from nine neovascular AMD patients 57 (Table 1). Interestingly, a study performed on RPE cells and RPE and choroid human samples unveiled LINC00167 as a protective factor against CNV.…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…54,55 LncRNAs expression and functions have been investigated in AMD murine models and human samples, unveiling the alteration of different lncRNAs. 57,58 In particular, 128 lncRNAs able to target angiogenetic genes and 744 lncRNAs binding factors involved in inflammation and immunity pathways were reported to be altered in CNV mice models compared to controls. Moreover, H19 lncRNA has been found increased in vitreous humor collected from nine neovascular AMD patients 57 (Table 1).…”

Section: Non-coding Rnasmentioning

confidence: 99%

Epigenomic signatures in age-related macular degeneration: Focus on their role as disease modifiers and therapeutic targets

Caputo

Strafella

Termine

et al. 2021

European Journal of Ophthalmology

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Epigenetics is characterized by molecular modifications able to shape gene expression profiles in response to inner and external stimuli. Therefore, epigenetic elements are able to provide intriguing and useful information for the comprehension and management of different human conditions, including aging process, and diseases. On this subject, Age-related Macular Degeneration (AMD) represents one of the most frequent age-related disorders, dramatically affecting the quality of life of older adults worldwide. The etiopathogenesis is characterized by an interplay among multiple genetic and non-genetic factors, which have been extensively studied. Nevertheless, a deeper dissection of molecular machinery associated with risk, onset, progression and effectiveness of therapies is still missing. In this regard, epigenetic signals may be further explored to disentangle disease etiopathogenesis, the possible therapeutic avenues and the differential response to AMD treatment. This review will discuss the epigenomic signatures mostly investigated in AMD, which could be applied to improve the knowledge of disease mechanisms and to set-up novel or modified treatment options.

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Analysis of Long Noncoding RNAs in Choroid Neovascularization

Cited by 10 publications

References 35 publications

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

RNA-seq analysis reveals differentially expressed inflammatory chemokines in a rat retinal degeneration model induced by sodium iodate

Epigenomic signatures in age-related macular degeneration: Focus on their role as disease modifiers and therapeutic targets

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