Abstract:The noncoding RNA (ncRNA) revolution has revealed myriad RNA species that play critical roles at all stages of life, including developmental biology and disease progression. For example, two long ncRNAs (lncRNA), Metastasis Associated Lung Adenocarcinoma Transcript‐1 (MALAT1; ~6.7 kb) and Second Chromosome Locus Associated with Prostate‐1 (SChLAP1; ~1.5 kb), are basally expressed in normal prostate tissue but are dysregulated in prostate cancer. MALAT1 acts in trans at nuclear speckles during mRNA post‐transcr… Show more
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