Analysis of Left Atrial Performance in Patients with Type 2 Diabetes Mellitus without Overt Cardiac Disease and Inducible Ischemia: High Prevalence of Increased Systolic Force Related to Enhanced Left Ventricular Systolic Longitudinal Function

Mazzone, Carmine; Cioffi, Giovanni; Faganello, Giorgio; Faggiano, Pompilio; Candido, Riccardo; Cherubini, Antonella; Tarantini, Luigi; Feo, Stefania De; Lenarda, Andrea Di

doi:10.1111/echo.12639

Cited by 1 publication

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“…Previous studies have demonstrated that both LA size and function are markers of LV diastolic dysfunction and prognostic markers for adverse cardiovascular events [ 4 , 5 , 15 ]. However, those studies focused on volume or mechanics, and none has quantitatively assessed LA blood flow dynamics in T2DM patients and the relationship with glycemic control.…”

Section: Introductionmentioning

confidence: 99%

“…It is considered a useful indicator of the efficiency of blood flow transfer and can reflect superfluous cardiac afterload caused by turbulent flow [ 17 ]. On the other hand, LA mechanics are impaired in T2DM patients [ 5 ]. With advances in the non-invasive evaluation of atrial function, STE is increasingly used to assess LA function, given its relative angle independence and ability to assess global atrial mechanics [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Early Detection of Left Atrial Energy Loss and Mechanics Abnormalities in Diabetic Patients with Normal Left Atrial Size: A Study Combining Vector Flow Mapping and Tissue Tracking Echocardiography

Wang

Hou

et al. 2016

Med Sci Monit

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BackgroundWhether left atrial (LA) functional abnormalities already exist when the LA is of normal size is unknown. The aim of this study was to explore LA energy loss and mechanics changes using vector flow mapping (VFM) and two-dimensional tissue tracking (2DTT) echocardiography in patients with diabetes and normal LA size.Material/MethodsThis study included 47 normotensive patients with diabetes and 45 controls. The following indexes were measured: LA energy loss during systole (LAELs), early diastole (LAELed), and atrial contraction (LAELac); atrial longitudinal strain during systole (SLAs), early diastole (SLAed) and late diastole (SLAac); and peak LA strain rate during systole (SRLAs), early diastole (SRLAed), and atrial contraction (SRLAac).ResultsThe LAELs and LAELed decreased in diabetic patients compared with controls (P=0.002, P<0.01, respectively), whereas the LAELac increased in diabetic patients (P<0.001). The SLAs, SLAed, SRLAs, and SRLAed (all P<0.01) were all lower in diabetic patients than in controls. However, there was no difference in the SLAac and SRLAac between the two groups. Multivariate regression analysis showed that the LAELs, LAELac, and SRLAs were independently associated with HbA1c in the whole study population.ConclusionsLA energy loss and deformation mechanics are already impaired in diabetic patients with normal LA size and the long-term parameter of glycemic control was correlated with them. VFM combined with 2DTT might be a promising tool for the early detection of LA dysfunction caused by impaired glucose metabolism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early Detection of Left Atrial Energy Loss and Mechanics Abnormalities in Diabetic Patients with Normal Left Atrial Size: A Study Combining Vector Flow Mapping and Tissue Tracking Echocardiography

Wang

Hou

et al. 2016

Med Sci Monit

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Analysis of Left Atrial Performance in Patients with Type 2 Diabetes Mellitus without Overt Cardiac Disease and Inducible Ischemia: High Prevalence of Increased Systolic Force Related to Enhanced Left Ventricular Systolic Longitudinal Function

Abstract: High LASF is present in one third of T2DM patients without overt cardiac disease and is positively and independently related to an increased LV longitudinal shortening function, suggesting a close interaction between LV systolic and diastolic function.

Cited by 1 publication

References 31 publications

Early Detection of Left Atrial Energy Loss and Mechanics Abnormalities in Diabetic Patients with Normal Left Atrial Size: A Study Combining Vector Flow Mapping and Tissue Tracking Echocardiography

Early Detection of Left Atrial Energy Loss and Mechanics Abnormalities in Diabetic Patients with Normal Left Atrial Size: A Study Combining Vector Flow Mapping and Tissue Tracking Echocardiography

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