Analysis of Laparoscopy-assisted Gastric Cancer Operations Performed by Inexperienced Junior Surgeons

Zhang, Xingmao; Wang, Zheng; Liang, Jianwei; Zhou, Zhixiang

doi:10.7314/apjcp.2014.15.12.5077

Cited by 3 publications

(2 citation statements)

References 24 publications

(21 reference statements)

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“…Gastric cancer is one of the most common and lethal malignancies, and is the third leading cause of cancer-associated mortality worldwide (1). The incidence of gastric cancer in China accounts for >40% of newly diagnosed patients with gastric cancer in the world (2)(3)(4). At present, the pathogenesis of gastric cancer remains unclear; however, it is hypothesised that several factors, multiple steps and multiple genes serve important roles in gastric cancer pathogenesis (5,6).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter�pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells

et al. 2018

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Helicobacter pylori (H. pylori) infection is the most important factor in the development of gastric cancer. Heparanase (HPA) is involved in tissue remodelling and cell migration, which leads to inflammation and tumour metastasis. The current study aimed was to explore whether a H. pylori infection leads to an increase in the level of HPA in gastric cancer and to investigate the specific mechanism underlying this association. Reverse transcription-polymerase chain reaction and western blotting were used to detect HPA mRNA and protein expression, respectively, in MKN-45 cells infected by H. pylori, MKN-45 cells treated with the mitogen-activated protein kinase (MAPK) inhibitor SB203580 and MKN-45 cells transfected with small interfering RNA against HPA. MAPK and nuclear factor (NF)-κB expression were determined by western blotting in the different cells group. Cell Counting Kit-8, Transwell method, and Scratch and Clone tests were conducted to detect proliferation, invasion, migration and clone formation ability of gastric cancer cells. It was demonstrated that HPA mRNA expression was highest at 6 h post-infection, while the expression of the HPA protein was highest at 24 h post-infection in H. pylori-infected gastric cancer cells. Furthermore, it was demonstrated that H. pylori infection significantly enhanced the expression of MAPK and NF-κB in MKN-45 cells at the mRNA and protein levels. SB203580 significantly decreased the expression of NF-κB in MKN-45 cells infected with H. pylori. Exposure to SB203580 also significantly decreased the expression of HPA. In the present study, the inhibition of HPA significantly lowered H. pylori-induced cell proliferation, suggesting that H. pylori infection induces the proliferation of gastric cancer cells through the upregulation of HPA. Taken together, the results of the present study demonstrated that HPA serves a critical role in the development of gastric cancer in H. pylori-infected cells, which may be an important mechanism through which H. pylori infection leads to gastric cancer. In addition, H. pylori infection promotes the proliferation, invasion and metastasis of gastric cancer cells through the upregulation of HPA expression, and this is likely mediated via the MAPK and NF-κB signalling pathways. These data suggest that HPA can be used as a therapeutic target in gastric cancer, particularly in cases induced by H. pylori infection.

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Section: Introductionmentioning

confidence: 99%

Helicobacter�pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells

et al. 2018

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“…But CT scan does not totally exclude liver and peritoneal metastasis (Kapiev et al, 2010;Makino et al, 2011). Technique of laparoscopy-assisted gastric cancer resection was reported widely (Zhang et al, 2014). Laparoscopy may detect occult metastatic diseases and spare the patient an unnecessary laparotomy, result in fewer complications, and reduce the substantial morbidity and mortality associated with nontherapeutic laparotomy (Karanicolas et al,.…”

Section: Introductionmentioning

confidence: 99%

Three-Port Laparoscopic Exploration is not Sufficient for Patients with T4 Gastric Cancer

Huang

Jin

Long

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Gastric cancer continues to be a leading cause of cancer death. The majority of patients with gastric adenocarcinoma in China present with advanced disease. Ruling out unresectable cancers from an unnecessary ''open'' exploration is very important. The aim of this study was to assess the value of five-port anatomical laparoscopic exploration in T4 gastric cancer in comparison with three-port laparoscopic exploration and laparotomy exploration. We conducted a retrospective study on 126 patients with T4 stage scheduled for D2 curative gastrectomy based on computed tomography (CT) staging at Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, from Apr. 2011 to Apr. 2013. Laparotomy exploration (Group I), three-port laparoscopic exploration (Group II) or five-port anatomical laparoscopic exploration (Group III) were performed prior to radical gastrectomy. Accuracy rate for feasibility of D2 curative gastrectomy in laparotomy exploration and five-port anatomical laparoscopic exploration groups was higher than that in the three-port laparoscopic exploration group. Five-port anatomical laparoscopic exploration group had the highest accuracy resection rate (Group I vs Group II vs Group III,92.6% vs78.6% vs 97.7%; p<0.05) and shorter length of hospitalization (Group I vs Group II vs Group III, 9.58±4.17 vs 6.13±2.85 vs 5.00±1.81; p<0.001). Three-port laparoscopic exploration has low accuracy rate for assessing feasibility of D2 curative gastrectomy and five-port anatomical laparoscopic exploration should be performed on patients with T4 gastric cancer.

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Outcome after Simultaneous Resection of Gastric Primary Tumour and Synchronous Liver Metastases: Survival Analysis of a Single-center Experience in China

Liu¹,

Bi²,

Tian³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The optimal surgical strategy for the treatment of synchronous resectable gastric cancer liver metastases remains controversial. The aims of this study were to analyze the outcome and overall survival of patients presenting with gastric cancer and liver metastases treated by simultaneous resection. Materials and Methods: Between January 1990 and June 2009, 35 patients diagnosed with synchronous hepatic metastases from gastric carcinoma received simultaneous resection of both primary gastric cancer and synchronous hepatic metastases. The clinicopathologic features and the surgical results of the 35 patients were retrospectively analyzed. Results: The 5-year overall survival rate after surgery was 14.3%. Five patients survived for more than 5 years after surgery. No mortality has occurred within 30 days after resection, although two patients (5.7%) developed complications during the peri-operative course. Univariate analysis revealed that patients with the presence of lymphovascular invasion of the primary tumor, bilateral liver metastasis and multiple liver metastases suffered poor survival. Lymphovascular invasion by the primary lesion and multiple liver metastases were significant prognostic factors that influenced survival in the multivariate analysis (p=0.02, p=0.001, respectively). Conclusions: The presence of lymphovascular invasion of the primary tumor and multiple liver metastases are significant prognostic determinants of survival. Gastric cancer patients without lymphovascular invasion and with a solitary synchronous liver metastasis may be good candidates for hepatic resection. Simultaneous resection of both primary gastric cancer and synchronous hepatic metastases may effectively prolong survival in strictly selected patients.

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Analysis of Laparoscopy-assisted Gastric Cancer Operations Performed by Inexperienced Junior Surgeons

Cited by 3 publications

References 24 publications

Helicobacter�pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells

Helicobacter�pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells

Three-Port Laparoscopic Exploration is not Sufficient for Patients with T4 Gastric Cancer

Outcome after Simultaneous Resection of Gastric Primary Tumour and Synchronous Liver Metastases: Survival Analysis of a Single-center Experience in China

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