Analysis of laboratory values in horses with cardiac disease: Diagnostic value of different cardiac biomarkers

Gehlen, Heidrun; Rohn, Karl; Deegen, E; Städler, P

doi:10.21836/pem20060503

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Natomiast Gehlen i wsp. (14) w przeprowadzonych badaniach stwierdzili istotnie statystyczną różnicę w średniej aktywności HBDH pomiędzy końmi zdrowymi i końmi z chorobami serca o różnej etiologii, jednak pomimo uzyskania takiego wyniku nie uważają oni sercowego izoenzymu dehydrogenazy mleczanowej, jako wysoce specyficznego dla chorób serca, ponieważ u wielu koni ze zmianami patologicznymi serca aktywność HBDH nie przekraczała wartości stwierdzonych u koni zdrowych. Obserwacje przeprowadzone przez Gehlen i wsp.…”

Section: Ryc 4 śRednia Aktywność Całkowitej Dehydrogenazy Mleczanowej...unclassified

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Usefulness of determining some markers of myocardial damage in sports horses subjected to physical exertion

MAKSYMOVYCH¹,

SLIVINSKA²,

Kubiak³

et al. 2023

Medycyna Weterynaryjna

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The aim of the study was to evaluate the usefulness of determining markers of myocardial damage, such as: aspartate aminotransferase, total creatine kinase, cardiac creatine kinase isoenzyme, total lactate dehydrogenase, cardiac lactate dehydrogenase isoenzyme and peripheral blood lactic acid in sport horses subjected to physical exertion. The research was carried out on 50 horses of three breeds: Ukrainian Riding, Hanoverian and Westphalian, aged 4-16 years. In all horses, the activity of: aspartate aminotransferase, total creatine kinase, cardiac creatine kinase isoenzyme, total lactate dehydrogenase, cardiac isoenzyme lactate dehydrogenase and lactic acid concentration were marked before and after exercise. It was found that after physical exercise in the tested horses, there was an increase in markers of myocardial damage. On the basis of the conducted research, it was demonstrated that the highest increase concerned the concentration of lactic acid and the activity of the cardiac isoenzyme of creatine kinase. The conducted studies additionally indicate that the evaluation markers of myocardial damage in horses may be useful as a screening test in detecting cardiac muscle disorders associated with excessive exercise. However, it should be emphasized that it must be considered together with the results of a clinical examination and additional tests such as cardiac ultrasound and electrocardiography.

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Section: Ryc 4 śRednia Aktywność Całkowitej Dehydrogenazy Mleczanowej...unclassified

“…Obserwacje przeprowadzone przez Gehlen i wsp. (14) są potwierdzeniem wcześniejszych badań przeprowadzonych przez Nuytten i wsp. (32), którzy wykazali istotny statystycznie wzrost aktywności sercowego izoenzymu dehydrogenazy mleczanowej tylko u koni z ostrym uszkodzeniem mięśnia sercowego.…”

Section: Ryc 4 śRednia Aktywność Całkowitej Dehydrogenazy Mleczanowej...unclassified

Usefulness of determining some markers of myocardial damage in sports horses subjected to physical exertion

MAKSYMOVYCH¹,

SLIVINSKA²,

Kubiak³

et al. 2023

Medycyna Weterynaryjna

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show abstract

“…However, post-exercise increases in cTnI levels are common in active horses and must be distinguished from pathological increases, as pointed out by Lippi and Sanchis-Gomar [19]. In fact, cTnI only enters circulation when myocardial cells are under increased stress [18,[20][21][22][23][24][25]. Studies on endurance horses [26][27][28] reported an increase in cTnI levels after endurance rides, while Fazio et al [29] found cTnI increases after jump training in healthy horses.…”

Section: Introductionmentioning

confidence: 99%

Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift

Giers,

Bartel,

Kirsch

et al. 2023

Animals

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Horses competing in cross-country tests are subjected to high physical demands. Within the scope of this prospective longitudinal study, blood values of 20 elite eventing horses were examined before and after two- to four-star cross-country rides. The aim was to find out whether blood-based markers for skeletal muscle and cardiac muscle function change after cross-country exercise. Parameters that provide information about fluid balance, muscle enzymes, metabolites and cardiac muscle-specific markers were investigated. We developed an approach to eliminate the concentration changes caused by reduced plasma volume. Parameters were measured pre, 10 and 30 min post exercise and the next morning and were evaluated using a mixed model. Thirty minutes after exercise, most parameter concentrations changed in an exercise-dependent manner. The next morning, most exercise-related markers recovered rapidly, while creatine kinase (CK) (26% increase; p = 0.008) and lactate dehydrogenase (LDH) (15% increase; p < 0.001) showed a declining but sustained increase. Cardiac troponin I (cTnI) increased above the reference range in 40 of the 55 rides (73%) and in 18 of 20 horses in the morning after exercise.

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Cardiac Arrhythmias in Standardbreds During and After Racing—Possible Association Between Heart Size, Valvular Regurgitations, and Arrhythmias

Buhl

Petersen

Lindholm

et al. 2013

Journal of Equine Veterinary Science

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Analysis of laboratory values in horses with cardiac disease: Diagnostic value of different cardiac biomarkers

Cited by 6 publications

References 6 publications

Usefulness of determining some markers of myocardial damage in sports horses subjected to physical exertion

Usefulness of determining some markers of myocardial damage in sports horses subjected to physical exertion

Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift

Cardiac Arrhythmias in Standardbreds During and After Racing—Possible Association Between Heart Size, Valvular Regurgitations, and Arrhythmias

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