The existing analysis methods of grid operation weakness have gradually been unable to meet the application needs of new power systems. The continuous development of artificial intelligence technology such as knowledge graph provides a new solution for this problem. Therefore, this paper proposes an Analysis Method of Power Grid Operation Weakness Based on Knowledge Graph. Through natural language processing technology, a variety of grid operation data are analyzed, and the knowledge graph of grid operation weakness analysis is designed and constructed. Then, based on the knowledge graph and Inference rules, the analysis results of traditional methods are reasoned and optimized. Finally, the grid operation weakness analysis is realized by the knowledge, model dual driving. The practical application shows that this method improves the situation awareness and analysis ability of power dispatchers to the grid operation weakness, and provides a basis for the automatic generation of fault preplan and other applications.