Analysis of key markers: IL-10/sHLA-G in psoriasis patients and the identification of 14-bp INDEL in the HLA-G gene

BIENIEK-KOBUSZEWSKA, Martyna; Owczarczyk‐Saczonek, Agnieszka; Maciejewska-Radomska, Agata; WOJTACHA, Paweł; Placek, Waldemar

doi:10.23736/s2784-8671.20.06878-9

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…HLA-G shows expression in autoimmune skin disorders [21] and could be present in NS-V lesions. The SNVs in their gene associated with the level of in situ expression of the molecule, could contribute to the risk of developing NS-V, recalling their role in the homeostasis, pigmentation, and regulation of the immune response in the skin [22].…”

Section: Discussionmentioning

confidence: 99%

Association of the HLA-G rs66554220 variant with non-segmental vitiligo and its clinical features in Northwestern Mexico population

Becerra-Loaiza¹,

Ochoa‐Ramírez²,

Velarde‐Félix³

et al. 2023

pdia

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Introduction The HLA-G molecule functions as a critical immunomodulatory checkpoint, its expression is significantly associated with pathological processes that may be responsible in part for autoimmune conditions such as non-segmental vitiligo (NS-V), characterized by chronic skin depigmentation. In this sense, the rs66554220 (14 bp ID) variant located in the 3’UTR, implicated in the regulation of HLA-G production, is associated with autoimmune diseases. Aim To evaluate the role of the HLA-G rs66554220 variant in NS-V and its clinical features in Northwestern Mexicans. Material and methods We genotyped the rs66554220 variant by SSP-PCR in 197 NS-V patients and 198 age-sex matched non-related healthy individuals (HI). Results Del allele and genotype Del/Ins were the most prevalent in both study groups (NS-V/HI = 56%/55% and 46.70%/46.46%, respectively). Despite lacking association between the variant and NS-V, we found an association of the Ins allele in different inheritance models with familial clustering, onset of the illness, universal clinical subtype and Koebner’s phenomenon. Conclusions The rs66554220 (14 bp ID) variant is not a risk factor for NS-V in the Mexican population studied. To our knowledge, this is the first report about the topic in the Mexican population and worldwide that includes clinical features related with this HLA-G genetic variant.

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Section: Discussionmentioning

confidence: 99%

Association of the HLA-G rs66554220 variant with non-segmental vitiligo and its clinical features in Northwestern Mexico population

Becerra-Loaiza¹,

Ochoa‐Ramírez²,

Velarde‐Félix³

et al. 2023

pdia

View full text Add to dashboard Cite

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“…[ 19 ] IL-10 was related to the pathogenesis or development of autoimmune diseases. Borska et al [ 13 ] indicated that the level of IL-10 in psoriatic patients was higher than that in the healthy controls, while Bieniek-Kobuszewska et al [ 20 ] demonstrated that the serum level of IL-10 in psoriasis was lower than that in the healthy controls. Bai et al [ 21 ] found that there was no significant difference in the level of IL-10 compared with the healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Profiles and the Relationship of Disease Severity in Patients with Psoriasis

Wang

Yan

Zheng

et al. 2022

Indian Journal of Dermatology

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Background: Psoriasis is a chronic skin disease characterized by hyperproliferation of keratinocytes and increased inflammation. Previous studies have detected the levels of cytokines in the serum of patients with psoriasis, yet few multi-cytokine combination studies have been reported. Objective: The aim of the study was to compare the levels of cytokines in the serum between patients with psoriasis and healthy controls, elucidate which factors influence the psoriasis progression. Methods: A total of 39 psoriasis patients and 30 healthy volunteers were enrolled. The venous blood was collected and the levels of 13 inflammatory cytokines were measured by human inflammation panel 1 kit. The severity of the disease was determined according to the psoriasis area and severity index (PASI) score. Results: Compared with healthy controls, the levels of nine cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-10, IL-12P40, IL-18, IL-17A and IL-23) were significantly increased, while the level of MCP-1 decreased in psoriatic patients. In addition, except for MCP-1, IL-10 and IL-12P40, these cytokine levels were positively correlated with the PASI score. Furthermore, there were higher serum lever of IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, IL-18 and IL-23 in active psoriasis than healthy controls and retrograde psoriasis. Conclusions: Increased serum levels of IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, IL-18 and IL-23 in psoriatic patients were associated with PASI and the stage of disease, which suggested that these cytokines play an important role in the pathogenesis of psoriasis. The detection of these cytokines can better observe the disease activity of psoriasis and optimize the treatment strategy.

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Analysis of key markers: IL-10/sHLA-G in psoriasis patients and the identification of 14-bp INDEL in the HLA-G gene

Cited by 2 publications

References 40 publications

Association of the HLA-G rs66554220 variant with non-segmental vitiligo and its clinical features in Northwestern Mexico population

Association of the HLA-G rs66554220 variant with non-segmental vitiligo and its clinical features in Northwestern Mexico population

Cytokine Profiles and the Relationship of Disease Severity in Patients with Psoriasis

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