Analysis of kanamycin sulfate by liquid chromatography with pulsed electrochemical detection

Charged aerosol detection in pharmaceutical analysis

“…Numerous papers describing LC methods for the identification and control of impurities in aminoglycoside antibiotics using detection by UV-spectrophotometry [29,30], mass spectrometry [31], and pulsed amperometric detection (PAD) [32][33][34][35][36][37][38][39] have been published. Unfortunately, each of these methods has major disadvantages.…”

Hollow fiber supported ionic liquid membrane microextraction for preconcentration of kanamycin sulfate with electrochemiluminescence detection

“…1) belongs to an important group of aminoglycosides used to prevent infections, treat diseases and promote growth. As a second-line treatment of mycobacterium tuberculosis, it has narrow therapeutic rang and is potentially oto-and nephrotoxic like other aminoglycosides [1]. Aside from this application, kanamycin is currently only used for treatment of mastitis in dairy cattle [2] and as a growth promoter in animal food [3].…”

Occurrence and behavior of system peaks in RP HPLC with solely aqueous mobile phases

“…Solely aqueous mobile phases without any organic modifier are environment-friendly therefore, their use is favorable. Such RP separation systems have been used for example for analysis of broad spectra aminoglycoside antibiotics [1,2] or nucleotides [3]. These mobile phase compositions are quite similar to background electrolyte (BGE) compositions applied in capillary zone electrophoresis (CZE).…”