Analysis of IVF/ICSI outcomes in infertile women with early-stage endometrial cancer and atypical endometrial hyperplasia after conservative treatment

Guo, Yaxing; Zong, Xuan; Li, Hongzhen; Qiao, Jie

doi:10.1007/s10815-022-02475-3

Cited by 13 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gallos et al reported that the live birth rates of AEH and EC patients were 26.3% and 28% respectively, and the pregnancy rate of ART was higher than the probability of natural pregnancy (39.4% vs 14.9%) [3]. As compared to AEH, patients with EEC had a lower live birth rate and a higher relapse rate than AEH patients during IVF according to our previous studies [5,6]. This is due to a combination of factors including the recurrence of disease, damaged endometrium, diminished ovarian reserve, and obesity.…”

Section: Introductionmentioning

confidence: 59%

Segmented in vitro fertilization and frozen embryo transfer in levonorgestrel-releasing intrauterine device treated patients with endometrial cancer

Wei¹,

Pan³

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose To evaluate the efficacy of levonorgestrel-releasing intrauterine device (LNG-IUD) during controlled ovarian stimulation (COS) in patients with early stage endometrioid endometrial cancer (EEC). Methods A retrospective study was conducted. The study population comprised patients with EEC who achieved complete response after fertility-sparing treatment from December 2018 to December 2021 and all the women who underwent COS had LNG-IUDs inserted in the uterine cavity. Results 16 patients were enrolled who underwent 26 COS cycles. The average age was 33.19 ± 4.04 years. 12 patients had 19 subsequent frozen-thawed embryo transfer (FET) cycles, no embryos were obtained in 1 patient, 1 patient got pregnancy spontaneously with term delivery after COS, 1 patient relapsed before FET, and 1 patient did not transfer embryos for personal reasons. Among 19 FET cycles, the clinical pregnancy and live birth rates in each ET cycle were 36.84% (7/19) and 26.32% (5/19), respectively. 7 clinical pregnancies resulted in 2 miscarriages (28.57%), and 5 live births (71.43%). Totally 6 patients achieved 7 live births, the cumulative live birth rate was 37.5% (6/16). Three (18.75%)of these patients relapsed after COS during the follow-up period(31.31 ± 15.89 months). Time interval from COS to relapse was 6.63,11.67 and 16.23 months respectively. Conclusion LNG-IUD may benefit the pregnancy and oncological outcomes of patients with EEC during COS.

show abstract

Section: Introductionmentioning

confidence: 59%

Segmented in vitro fertilization and frozen embryo transfer in levonorgestrel-releasing intrauterine device treated patients with endometrial cancer

Wei¹,

Pan³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…2. During drug therapy, frequent endometrial scrapings are required to assess the effect of treatment, which may lead to endometritis and thinning of endometrial damage in some patients ( 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in infertile patients with endometrial hyperplasia with or without atypia undergoing in vitro fertilization: the early-follicular long protocol is superior to midluteal long protocol

An,

Li,

Huang

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundAlthough in vitro fertilization (IVF) in infertile patients with endometrial hyperplasia is common after drug treatment, the pregnancy outcomes are often unsatisfactory. Till date, no studies have reported the outcome of patients with endometrial hyperplasia treated using early-follicular long (EL) protocol and midluteal long (ML) protocol.ObjectiveTo evaluate the pregnancy outcomes and disease prognosis of patients with endometrial hyperplasia with or without atypia undergoing IVF treatment with EL protocol or ML protocol.MethodsThis was a retrospective study in university-affiliated reproductive medical center. A total of 138 patients with endometrial hyperplasia undergoing IVF treatment were included to compare the pregnancy outcomes and disease prognosis between EL and ML protocols. We further matched 276 patients with normal endometrium to compare the pregnancy outcomes between patients with endometrial hyperplasia and patients with normal endometrium under different controlled ovarian stimulation (COS) protocol.ResultsIn patients with endometrial hyperplasia, the clinical pregnancy rate (CPR) and live birth rate (LBR) were significantly higher in EL protocol than in ML protocol (61.8% vs. 43.5%, P=0.032; 50.0% vs. 30.6%, P= 0.022). In the ML protocol, patients with endometrial hyperplasia had significantly lower CPR and LBR than those with normal endometrium (43.5% vs. 59.7%, P=0.037; 30.6% vs. 49.2%, P=0.016). While in the EL protocol, they achieved similar CPR and LBR as patients with normal endometrium (61.8% vs. 69.7%, P=0.232; 50.0% vs. 59.9%, P=0.156). In patients with endometrial hyperplasia, COS protocol was an independent factor affecting clinical pregnancy (adjusted odds ratio [OR] 2.479; 95% confidence interval [CI] 1.154-5.327) and live birth (adjusted OR 2.730; 95% CI 1.249-5.966). After 1–10 years of follow-up, no significant difference was found in the recurrence rate of endometrial lesions between both treatment groups.ConclusionsFor patients with endometrial hyperplasia undergoing IVF treatment, the EL protocol is superior to ML protocol, and in the EL protocol, they can achieve similar pregnancy outcomes as patients with normal endometrium.

show abstract

“…A viable embryo, a receptive endometrium, suitable embryo endometrial cross-talk, and appropriate maternal immune protection are all necessary for successful implantation (Afaf T and Mohamed, 2020). The implantation and pregnancy rates have barely changed despite breakthroughs in assisted reproductive technology (Scarpellini and Sbracia, 2020), (Guo, et al, 2022), (Goel, et al, 2020). Numerous researchers contend that patients' core and overall fertility quality of life, psychological health, and perceived treatment-related quality of life are all considerably lowered when infertility persists for longer than three years in both men and women (Zurlo, et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…A unique, nearly immortal tissue called the endometrium regenerates repeatedly for the precise purpose of ensuring the survival of our species. (Guo, et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

comparison between the effect of different medical drugs used to improve endometrial receptivity in patients with thin poorly vascularized endometrium

Tawfeeq¹,

Abbood

Jwad³

2022

ijhs

View full text Add to dashboard Cite

Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begins, and a receptive endometrium lies at the crossroads of menstruation and pregnancy. Aim of the study: To evaluate the effects of different medical drugs used routinely to improve endometrial thickness, vascularity, and pregnancy rates and to find out the best medical protocol could be used to improve endometrial thickness, vasculature, and pregnancy rate for patient with thin and poorly vascularized endometrium regardless the cause. Materials and methods: The study was carried out on 200 infertile women who have thin , poorly vascularized endometrium, after they matched the inclusion and exclusion criteria , those patients were divided randomly into five groups ; 40 patient in each group, group A received esterofem oral 2mg tablet every 12 hours from day 2 of menstrual cycle till the day of ovulation trigger , group B received vagifem vaginal tablets 25 microgram from the fourth day of menstrual cycle for 15 days or till the day of ovulation trigger, group C received sildenafil citrate gel 3 gm which containing 37.5 mg sildenafil every 12 hours from the 2nd day of menstruation till the day of ovulation trigger.

show abstract

Analysis of IVF/ICSI outcomes in infertile women with early-stage endometrial cancer and atypical endometrial hyperplasia after conservative treatment

Cited by 13 publications

References 35 publications

Segmented in vitro fertilization and frozen embryo transfer in levonorgestrel-releasing intrauterine device treated patients with endometrial cancer

Segmented in vitro fertilization and frozen embryo transfer in levonorgestrel-releasing intrauterine device treated patients with endometrial cancer

Pregnancy outcomes in infertile patients with endometrial hyperplasia with or without atypia undergoing in vitro fertilization: the early-follicular long protocol is superior to midluteal long protocol

comparison between the effect of different medical drugs used to improve endometrial receptivity in patients with thin poorly vascularized endometrium

Contact Info

Product

Resources

About