Analysis of interleukin‐23 receptor (<i>IL23R</i>) gene polymorphisms in systemic lupus erythematosus

Sánchez, Elena; Rueda, Blanca; Callejas‐Rubio, José Luis; Sabio, JM; Ortego-Centeno, Norbérto; Jiménez-Alonso, J; Ma, Li-na; Martin, Jose-Ezequiel

doi:10.1111/j.1399-0039.2007.00881.x

Cited by 40 publications

(23 citation statements)

References 36 publications

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“…IL-23 is one of the important proinflammatory cytokines that is associated with multiple autoimmune diseases, including SLE [32]. Recently several studies have evaluated the association between the IL-23R gene rs7517847 T>G SNP and SLE susceptibility [26][27][28][29]. Because of inconsistencies in the results, a metaanalysis was needed.…”

Section: Discussion ____________________________mentioning

confidence: 99%

“…The initial search yielded 463 potentially relevant articles. According to the inclusion criteria, a total of four case-control studies with 1348 SLE cases and 1754 healthy subjects were included in this meta-analysis [26][27][28][29]. The studies were done in different regions: one in China [26], one in Hungary [27], one in Spain [28], and one in South Korea [29].…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

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Association of IL-23R gene rs7517847 T>G SNP and susceptibility to systemic lupus erythematosus: A systematic review and meta-analysis

et al. 2018

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Previous articles have evaluated the association between IL-23R gene rs7517847 T>G SNP and systemic lupus erythematosus (SLE). Nevertheless, the results of these studies have been inconclusive. The current study is a meta-analysis that assesses the association between IL-23R gene rs7517847 T>G SNP and SLE susceptibility. Literature searches of Medline, Web of Science, and EMBASE databases were performed to recognize all eligible studies published before August, 2016, and the search was updated in July, 2017. The identified studies were independently reviewed by two authors for eligibility based on inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to assess the strength of association in the allelic model, dominant model, recessive model, heterozygotes contrast, and homozygotes contrast. Because evidence of heterogeneity was detected across the studies, the data was pooled using a random-effects model. A sum of four case-control studies with 1348 SLE patients and 1754 healthy subjects were considered in this study. In the combined analysis, no significant association between the IL-23R gene rs7517847 T>G SNP and SLE disease risk was found in any of the genetic models (dominant model: OR = 0.95, 95% CI = 0.72-1.18; allelic model: OR = 1.08, 95% CI = 0.95-1.21; recessive model: OR = 1.13, 95% CI = 0.80-1.46; TG vs. TT: OR = 0.86, 95% CI = 0.63-1.08; and GG vs. TT: OR = 1.20, 95% CI = 0.81-1.60). Moreover, no publication bias was observed in any genetic models (p> 0.05). First, this study was based on unadjusted ORs. Second, the number of included case-control articles was small. Third, only published English language studies were imported to this meta-analysis. The current meta-analysis suggests that the IL-23R gene rs7517847 T>G SNP might not be related with risk of SLE. More studies are essential to confirm these results. No association was found between the IL-23R gene rs7517847 T>G SNP and SLE risk.

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Section: Discussion ____________________________mentioning

confidence: 99%

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

Association of IL-23R gene rs7517847 T>G SNP and susceptibility to systemic lupus erythematosus: A systematic review and meta-analysis

et al. 2018

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“…[31][32][33] In contrast, no association was found between IL-23R gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus. 34,35 Because of the similarities between the clinical and immunological aspects of inflammatory bowel disease and AS, scientific studies investigating the impact of genetic factors on AS development focused on the relationship between AS and IL-23R gene polymorphism. 10 Previous studies have conflicting results since there is no consensus whether IL-23R gene polymorphism has a protective effect against or constitutes a risk factor for AS.…”

Section: Discussionmentioning

confidence: 99%

Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis

et al. 2016

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Objectives: This study aims to investigate the distribution of human leukocyte antigen B27 (HLA-B27) alleles (+/-) and interleukin-23 receptor (IL-23R) gene rs11209032 and rs1004819 polymorphisms among ankylosing spondylitis (AS) patients in a Turkish cohort. Patients and methods:The study sample comprised 106 AS patients (89 males, 18 females; mean age 38.9±10 years; range 19 to 65 years) and 82 healthy controls (70 males, 12 females; mean age 32.15±7.07 years; range 19 to 51 years). Distribution of HLA-B27 alleles (+)/(-) in AS patients were observed by reverse hybridization technique. Genotyping of IL-23R rs11209032 and rs1004819 polymorphisms of AS patients and healthy controls were performed by real time polymerase chain reaction. Results: Of the AS patients, 69 (65.1%) were HLA-B27 positive. Distribution of rs11209032 genotype frequencies in AS group were 31.1% for GG, 50.9% for GA, and 17.9% for AA; while in control group, it was 34.1% for GG, 53.7% for GA, and 12.2% for AA. Distribution of rs1004819 genotype frequencies in AS group were 30.2% for CC, 52.8% for CT, and 17.0% for TT; while in control group, it was 42.7% for CC, 46.3% for CT, and 11.0% for TT. There was no significant difference between AS patients and controls in terms of genotype frequencies of IL-23R gene rs11209032 and rs1004819 polymorphisms. Conclusion: No association was found between AS and IL23R rs11209032 and rs1004819 polymorphisms in this Turkish AS cohort.

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“…In this disease, the role of IL-17 is better characterized, while that of IL-23 is less clear. Indeed, there is no association with IL-23 genetic variants and SLE [5]. This evidence may suggest that ERAP1 is quite associated with an IL-23 rather than an IL-17 milieu.…”

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confidence: 92%

Discovering the pathogenesis of autoimmune diseases at the 9th International Congress of Autoimmunity, Nice, France, 2014

Perricone

Valesini

2014

Immunol Res

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Analysis of interleukin‐23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus

Cited by 40 publications

References 36 publications

Association of IL-23R gene rs7517847 T>G SNP and susceptibility to systemic lupus erythematosus: A systematic review and meta-analysis

Association of IL-23R gene rs7517847 T>G SNP and susceptibility to systemic lupus erythematosus: A systematic review and meta-analysis

Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis

Discovering the pathogenesis of autoimmune diseases at the 9th International Congress of Autoimmunity, Nice, France, 2014

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