Analysis of interactions between streptomycin sulphate and aqueous food acids (L-ascorbic acid and citric acid): Physico-chemical and spectroscopic insights

Sharma, Taniya; Kumar, Ashwani; Shah, Shahid Shafi; Bamezai, Rajinder K.

doi:10.1016/j.jct.2020.106207

Cited by 17 publications

(6 citation statements)

References 48 publications

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“…These values are found to be positive and larger in aqueous maline than in water. This may possibly be due to the caging/packing effect − In other words, on shifting the solvent from water to aqueous maline, the volume of the hydration shells of domiphen bromide/semicarbazide hydrochloride increases; this in turn leads to an increase in the expansivity of solutions. OIn addition, with elevation in temperature, E 0 ϕ values are advancing, which evidently reveals the dehydration of hydrated drugs by temperature.…”

Section: Results and Discussionmentioning

confidence: 99%

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

et al. 2022

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A comprehensive examination of the thermophysical properties of semicarbazide hydrochloride and domiphen bromide in water and aqueous maline solutions (maline, a deep eutectic solvent (DES) made by mixing choline chloride and malonic acid in 1:2 mol ratio) has been done by a combination of ultrasonic, volumetric, viscometric, and thermodynamic methods at the temperature range from 293.15 to 318.15 K. Exploration of molecular interactions through the procured thermophysical properties is very important because it provides an insight into the forces that are operating in the liquid mixtures. In the present study, thermophysical parameters such as apparent molar volume (V ϕ ), apparent molar isentropic compressibility (K ϕ,s ), viscosity coefficients, Hepler's constant, etc. are studied for the abovementioned drugs in water and aqueous maline solutions. The results revealed the dominance of solute−solvent interactions in the studied systems, which were found to escalate with elevation in temperature and with the concentration of maline. The results are discussed in terms of hydrophilic−hydrophilic and hydrophilic−hydrophobic interactions in these systems along with the structure breaking/making ability of the drugs. The co-sphere overlap model has been used to interpret the positive transfer values.

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Section: Results and Discussionmentioning

confidence: 99%

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

et al. 2022

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“…Streptomycin sulfate is an aminoglycoside antibiotic whose molecular structure contains an abundance of functional groups that can integrate with heavy metal ions, such as -OH and -NH 2 . 10 In this work, using a chemical grafting method, we prepared an alginate-streptomycin sulfate composite aerogel (Alg-Stre) and analyzed its physical and chemical properties as well as its ability to adsorb heavy metal ions from wastewater under different environmental conditions. The macroscopic and microscopic morphologies of the materials were acquired using a Quanta FEG-250 scanning electron microscope (SEM, FEI Company, Hillsboro, Oregon, USA) and a Canon D600 digital camera, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Streptomycin sulfate is an aminoglycoside antibiotic whose molecular structure contains an abundance of functional groups that can integrate with heavy metal ions, such as –OH and –NH 2 . 10 In this work, using a chemical grafting method, we prepared an alginate–streptomycin sulfate composite aerogel (Alg–Stre) and analyzed its physical and chemical properties as well as its ability to adsorb heavy metal ions from wastewater under different environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Effective removal of lead and copper ions from water using a novel sodium alginate–streptomycin sulfate composite aerogel

et al. 2023

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“…Gentamicin (GEN) is a highly hydrophilic aminoglycoside antibiotic and is often used against a wide range of bacterial infections, such as P. aeruginosa , E. coli , and E. aerogenes , and is also used in the treatment of bone infections caused by S. aureus and many others. − Several studies have reported the use of GEN in controlled drug delivery, as for example Rouabhia et al prepared gentamicin activated bacterial cellulose dressings containing 3-aminopropyltriethoxysilane (APTES) as a coupling agent for drug delivery and wound healing applications. Another widely researched aminoglycoside antibiotic is streptomycin (SM), which is also antibacterial and is mainly used in the treatment of serious infections caused by tuberculosis ( Mycobacterium tuberculosis ), plague ( Yersinia pestis ), and avium ( Mycobacterium avium ), and is considered as one of the most effective and safe medicines for human health system as documented by the World Health Organization (WHO). − …”

Section: Introductionmentioning

confidence: 99%

Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application

Das

Zandraa

Mudenur

et al. 2022

ACS Appl. Bio Mater.

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Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity. However, the lack of antibacterial activity slightly restricts its application as a wound dressing material. In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing. Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm −1 , 3400 cm −1 , and 2895 cm −1 , respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images. X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%). In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications. Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites. The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus. The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.

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Analysis of interactions between streptomycin sulphate and aqueous food acids (L-ascorbic acid and citric acid): Physico-chemical and spectroscopic insights

Cited by 17 publications

References 48 publications

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

Effective removal of lead and copper ions from water using a novel sodium alginate–streptomycin sulfate composite aerogel

Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application

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