Analysis of influencing factors related to elevated serum troponin I level for COVID-19 patients in Yichang, China

Fan, Zhixing; Yang, Jun; Zhang, Jing; He, Chao; Wu, Hui; Yang, Chaojun; Zheng, Tao; Ma, Cong; Xiang, Zujin; Zhai, Yueyang; Jiang, Jing; Qiu, Shao-qin; Yang, Jian

doi:10.21037/cdt-20-510

Cited by 9 publications

(6 citation statements)

References 21 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ndings on demographic and clinical/laboratory data of the two ICU cohorts con rmed previous studies that found that age and obesity may contribute to the severity of the disease, as assessed by the PaO2/FiO2 ratio, the APACHE II index, and length of ICU stay [24]. They also validate previous studies showing that a marker of heart injury such as troponin is associated with age and in ammation (IL-6) [25].…”

Section: Discussionsupporting

confidence: 84%

Dysbiosis: an indicator of COVID-19 severity in critically ill patients

Cuenca

Zaida

Serrano-Gómez

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Research into the association between the microbiome and SARS-CoV-2 infection and acute respiratory distress syndrome remains unclear. Here we examined the dynamics of the gut and respiratory microbiomes in severe COVID-19 cases in need of mechanical ventilation in the intensive care unit (ICU).Methods: We recruited 76 critically ill patients (48 with COVID-19 and 32 without COVID-19) and 17 healthy controls (HCs) and monitored them for up to 4 weeks. We analyzed the bacterial and fungal taxonomic profiles and loads of 232 gut and respiratory samples and we measured blood levels of Interleukin 6, IgG, and IgM in COVID-19 patients.Results: At ICU admission, bacterial composition and load in the gut and respiratory samples were altered in critically ill patients compared to HCs. Six bacterial species could discriminate ICU-COV(+) from ICU-COV(-) cases. During their time in the ICU, all patients experienced increased bacterial and fungal loads, decreased bacterial richness, and progressive changes in bacterial and fungal taxonomic profiles. In ICU-COV(+) patients, Pseudomonas was found positively and Streptococcus negatively correlated with the length of ICU stay. Respiratory bacterial signatures, associated with disease severity and inflammation markers, were predictive of death and a fecal dysbiosis score, associated negatively with PaO2/FiO2 ratio, could be used as an additional indicator for ICU admission.Conclusion: We propose using a high-throughput sequencing approach as an alternative to traditional isolation techniques to monitor the ICU-COV(+) patient infection.

show abstract

Section: Discussionsupporting

confidence: 84%

Dysbiosis: an indicator of COVID-19 severity in critically ill patients

Cuenca

Zaida

Serrano-Gómez

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…One study showed that 41 (22%) of admitted patients had myocardial injury and the mortality was similar among those with myocardial injury regardless of whether they had or did not have COVID-19 infection [47]. The included studies also examined the relationship between troponin level and mortality or the prevalence of elevated cardiac enzymes among hospitalized COVID-19 patients [35,39,41,44,51,52,54,58,61,66].…”

Section: N Resultsmentioning

confidence: 99%

Myocardial injuries among patients with COVID-19: a systematic review

Alali¹,

Smaisem²,

Alsheikh³

et al. 2021

Infez Med

View full text Add to dashboard Cite

This is a systematic review of the literature specifically aimed to explore myocardial injury in coronavirus disease-19 (COVID-19) patients who were hospitalized with severe complicated infections. The medical literature was examined through the large medical databases, including Medline, Ovid, PubMed, and Embase, over the last year between January 2020 and May 2021. The search terms used were a combination of ''myocardial injury'' AND ''COVID-19'' AND "Hospitalization". Then we applied a step to filter the results to select original research articles only evaluating the myocardial injuries in severe COVID-19 hospitalized patients. Selected trials mentioned the type of myocardial injury detected with the infection. A total of 245 articles were extracted. Considering the exclusion of ineligible articles, 42 articles appeared. A total of 42 articles were eligible and were included SUMMARY in the review. These studies included a total of 4326 COVID-19 patients. The 30-day mortality was found to be associated with increased cardiac troponin and myocardial infarction could be a systemic reaction rather than the direct action of COVID-19. Patients with myocardial injury were significantly older and with co-morbid conditions. Studies also found a correlation of higher concentrations of cardiac enzymes with disease severity and increased in-hospital mortality. Myocardial injury was a significant predictor for severe COVID-19 infection and in-hospital mortality. Cardiac enzymes should be monitored in hospitalized patients with severe COVID-19 infections.

show abstract

“…Therefore, increased Mb may be used as a determinant of adverse COVID-19 outcomes. Also, [50] Who observed that the percentages of patients COVID-19 and unvaccinated with elevated MYO concentration were greater in the group with raised TnI. The biomarker was specific to MYO for the acute assessment of myocardial infarction and coronary heart disease.…”

Section: Estimation Of Serum Myoglobin Concentrationsmentioning

confidence: 89%

Evaluation of some cardiac markers in relation to COVID-19 mRNA vaccine

Al-Azzawi¹,

AL-Eqabi²

2022

JBB

View full text Add to dashboard Cite

Background: Acute myocardial infarction (AMI) is a dangerous cardiovascular illness that has a significant impact on people's health. Several biomarkers, including Myoglobin and troponin I (cTnI) were utilized to diagnose AMI in recent decades. The Troponin I (cTnI) was designated as the "gold standard" cardiac biomarker for the prediction of cardiomyopathy. It's a heart muscle regulating protein found on normal myocyte actin filaments. When cardiac muscles are injured, cTnI, one of the main subunits of the cardiac troponin complex, is released into the circulation (e.g., myocardial infarction). Myoglobin denoted by (symbols Mb and MB) seems to be an iron-and o2-binding protein present in the vertebrate heart and skeletal muscle tissues and, more specifically, nearly all mammals. In humans, MB is only present in the bloodstream following muscle damage. Its primary function is to supply myocytes with oxygen. Also essential to nitric oxide hemostasis was myoglobin. Additionally, it facilitates the detoxification of response oxygen molecules from the body. MB is accountable for most vertebrate muscles' red hue.The aim: To assess the difference in the level of (MYOGLOBIN and TROPONIN_I) between patients with and without mRNA Vaccination. Methods: This study included 125 patients (65 male and 60 female) with vaccinated and non-vaccinated covid-19 with an age range of 20-69 years. These patients are divided into two main groups: 1. vaccinated (vaccinated with COVID-19 infection, vaccinated without COVID-19 disease, vaccinated recovered from the CoV-19 virus),2. unvaccinated (infected with the CoV-19 virus and non-vaccinated, recovered from covid-19 and unvaccinated). The outcome is measured using the Enzyme-linked immunosorbent assay (ELISA) technique. This study was conducted during the period from November 2021 to May 2022 at the Martyr Dr.

show abstract

Analysis of influencing factors related to elevated serum troponin I level for COVID-19 patients in Yichang, China

Cited by 9 publications

References 21 publications

Dysbiosis: an indicator of COVID-19 severity in critically ill patients

Dysbiosis: an indicator of COVID-19 severity in critically ill patients

Myocardial injuries among patients with COVID-19: a systematic review

Evaluation of some cardiac markers in relation to COVID-19 mRNA vaccine

Contact Info

Product

Resources

About