Analysis of influencing factors associated with Hp infection in H-type hypertension

Abstract

Objective to investigate the influencing factors of Helicobacter pylori (Hp) infection in patients with H type hypertension. Methods A total of 1089 patients with h-type hypertension who underwent physical examination in Lanzhou PetrochemicalCompany of petrochina in Lanzhou city, Gansu Province from May 2021 to September 2021 were selected as the research objects. All the patients were tested by 14C urea breath test and divided into Hp infected group (278 cases) and Hp non-infected group (811 cases) according to the test results. For collected age, sex and other general demographic indicators and determined systolic blood pressure (SBP) diastolic blood pressure (DBP) albumin (ALB) globulin (GLB) total protein (TP) albumin/globulin (ALB/GLB) uric acid (UA) triglyceride (TG) Total cholesterol (TC) High-density lipoprotein (HDL) Low density lipoprotein (LDL) fasting blood glucose (GLU) and other biochemical indicators were analyzed by univariate analysis and multivariate unconditiona Logistic regression analysis. Results Univariate analysis showed that albumin (ALB) in h-type hypertension patients in infection group was lower than that in lung infectiongroup, and the difference was statistically significant (T =3.383, P<0.05). Systolic blood pressure (SBP), globulin (GLB), triglyceride (TG) and fasting blood glucose (GLU) were higher than those in the non-infected group, but the differences were not statistically significant (ALL P>0.05). Diastolic blood pressure (DBP), total protein (TP), uric acid (UA), total cholesterol (TC) and low density lipoprotein (LDL) were higher than those in the non-infected group. There were no significant differences (all P>0.05); Multivariate non-conditional Logistic regression showed that high density lipoprotein (DHL) was an independent protective factor for Hp infection in h-type hypertension patients (OR=0.49, P<0.05). Conclusions Hp infection is associated with lipid metabolism disorder, and high density lipoprotein is a protective factor of HELICobacter pylori infection in patients with H type hypertension.