Analysis of incidence of COPD in 1142 hospitalized lung cancer patients

Jovanovic, D.; Pajic, N.V; Zdravkovic, Andrej; Adzic, Tanja

doi:10.1016/s0169-5002(00)80776-x

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cigarette smoking itself is associated with neutrophilic inflammation, which causes the increase of inflammatory markers in the exhaled breath and is involved in pathogenesis of chronic inflammation of respiratory airways [21]. Thus, patients suffering from lung cancer often show co-morbidities as chronic obstructive or non-obstructive pulmonary diseases and emphysema [22]. Therefore, interpretation of breath profile in patients with lung cancer is far from being monosymptomatic, as there are at least three main contributing pathological pathways to which deviations may be attributed:…”

Section: Introductionmentioning

confidence: 99%

Compounds enhanced in a mass spectrometric profile of smokers' exhaled breath versus non-smokers as determined in a pilot study using PTR-MS

et al. 2008

View full text Add to dashboard Cite

A pilot study has been carried out to define typical characteristics of the trace gas compounds in exhaled breath of non-smokers and smokers to assist interpretation of breath analysis data from patients who smoke with respiratory diseases and lung cancer. Exhaled breath was analyzed using proton transfer reaction-mass spectrometry (PTR-MS) for 370 volunteers (81 smokers, 210 non-smokers, 79 ex-smokers). Volatile organic compounds corresponding to product ions at seven mass-to-charge ratios (m/z 28, 42, 69, 79, 93, 97, 123) in the PTR-MS spectra differentiated between smokers and non-smokers. The Youden index (= maximum of sensitivity + specificity - 1, YI) as a measure for differentiation between smokers and non-smokers was YI = 0.43 for ions at the m/z values 28 (tentatively identified as HCN), YI = 0.75 for m/z = 42 (tentatively identified as acetonitrile) and YI = 0.53 for m/z = 79 (tentatively identified as benzene). No statistically significant difference between smokers and non-smokers was observed for the product ions at m/z = 31 and 33 (compounds tentatively identified as formaldehyde and methanol). When interpreting the exhaled breath of lung cancer or COPD patients, who often smoke, compounds appearing at the above-mentioned seven mass-to-charge ratios should be considered with appropriate care to avoid misdiagnosis. Validation studies in larger numbers of patients with more precise delineation of their smoking behavior and using additional analytical techniques such as GC/MS and SIFT-MS should be carried out.

show abstract

Section: Introductionmentioning

confidence: 99%