Analysis of incidence, mortality trends, and geographic distribution of breast cancer patients in Canada

Lagacé, François; Ghazawi, Feras M.; Le, Michelle; Rahme, Elham; Savin, Evgeny; Zubarev, Andrei; Alakel, Akram; Sasseville, Denis; Moreau, Linda; Meterissian, Sarkis; Litvinov, Ivan V.

doi:10.1007/s10549-019-05418-2

Cited by 25 publications

(22 citation statements)

References 36 publications

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“…Using the methodology of our previous studies on melanoma in Canada [1-3, 16, 17], we re-calculated the Russian official data using available demographic data from the census [21]. Instead of the standard error calculations (used in the analysis of the data by the Russian Ministry of Health) [20] we computed 95% CIs [23] (online suppl.…”

Section: Resultsmentioning

confidence: 99%

“…The overall age-standardized incidence rate in Russia was 4.27 cases/100,000 per year (4.07 cases/100,000 individuals per year for males and 4.55 cases/100,000 per year for females). In Canada, the overall age-standardized incidence was 9.63 (95% CI 9.56–9.70) cases per 100,000 individuals per year [16]. Similarly, in the USA the age-standardized incidence rate was 15.1 cases/100,000 individuals per year for men and 11.1 cases/100,000 individuals per year for women.…”

Section: Discussionmentioning

confidence: 99%

“…We re-analyzed the existing official data using novel approaches with the aim of improving our knowledge on epidemiological specifics of CM in this wide and multinational region of the world. We utilized the same methodology as in the recently published analysis of melanoma in Canada [1-3, 16, 17].…”

Section: Introductionmentioning

confidence: 99%

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Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

et al. 2020

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Background: Cutaneous melanoma (CM) incidence has been increasing around the world. The goal of this study is to describe geographic trends in incidence and mortality of CM in Russia between 2001 and 2017. Methods: To achieve this we used geo-informatic technique (mapping) and descriptive statistical analysis. Additionally, we studied the associations between ethnicity, geographic latitude/longitude, and CM incidence/mortality rates. We retrospectively analyzed the data from the Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, for the period of the study. Routine methods of descriptive epidemiology were used to study incidence and mortality rates by age groups, years, and jurisdictions (i.e., Federal Districts and Federal Subjects of Russia). Results: In total, 141,597 patients were diagnosed with melanoma in Russia over the period 2001-2017, of whom 62% were women. The overall agestandardized incidence and mortality rates were 4.27/100,000 and 1.62/100,000, respectively. Geographic mapping revealed north-to-south and east-to-west gradients. As the study was fully descriptive, retrospective, and based on official statistical reports, detailed characteristics of clinical forms, anatomic sites, Breslow depth, and treatments could not be analyzed. Conclusions: This study outlined the burden of melanoma in the Russian Federation, and the trends were similar to those observed in countries with similar latitudes and skin phenotype. The importance of the skin color gradient and recreational/cultural practices were some of the most important risk factors highlighted in this study for the development of melanoma in Russia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

et al. 2020

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“…Incidence and mortality data for oral cavity and oropharyngeal malignancies were extracted from 3 distinct but complementary population-based cancer databases (Canadian Cancer Registry [CCR], Le Registre Québécois du Cancer [LRQC], and Canadian Vital Statistics [CVS]) using the previously reported and established methods. 11 -34…”

Section: Methodsmentioning

confidence: 99%

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Ghazawi

Savin

et al. 2020

J Cutan Med Surg

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Background Oral cavity cancers (OCCs) and oropharyngeal cancers (OPCs) continue to be a major source of morbidity and mortality worldwide requiring the shared effort of numerous specialists. Tobacco and alcohol consumption have long been identified as risk factors for both OCC and OPC. In addition, human papilloma virus (HPV) is gaining its position as the main causal agent for OPC. Objective The objective of this study is to analyze the epidemiology of OCC and OPC in Canada. Methods Data pertaining to the year of diagnosis, the patient’s sex, age at the time of diagnosis, province/territory, city and postal code of oral cavity, and oropharyngeal malignancies diagnosed during 1992-2010 were extracted from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Results In total, 21 685 OCC cases and 15 965 OPC cases were identified from 1992 to 2010. Of those, 84.97% were oral cavity squamous cell carcinomas (SCCs), 88.10% were oropharyngeal SCCs, and both had a significant male predominance. While oral cavity SCC incidence stabilized over the study period, oropharyngeal SCC continued to increase. Oral cavity SCC incidence increased with age, while oropharyngeal SCC incidence peaked in the 50- to 59-year age group. Detailed geographic distribution analysis of patients at the provincial/territorial, city, and postal code levels identified several patient clusters. Conclusions This work highlights important epidemiological differences in trends between oral and oropharyngeal cancers, identifies high-incidence postal codes for each malignancy, and correlates incidence/mortality with known risk factors including alcohol/tobacco use and HPV infections, therefore providing a comprehensive understanding of epidemiology for these cancers in Canada.

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“…The initial manuscript underwent 2 rounds of peer review by 5 experts in the field from May 10 to September 8, 2018, at which point the article was endorsed for publication. For this initial study on AML, the research team followed the same approved protocol for data analysis that was used for a series of other published articles within approximately the last 2 years . In this study, we present additional analyses, which we hope will help to address the criticisms brought forward by experts in the research community.…”

Section: Introductionmentioning

confidence: 99%

Incidence of acute myeloid leukemia: A regional analysis of Canada

Ghazawi

Ramanakumar

Alakel

et al. 2019

Cancer

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Analysis of incidence, mortality trends, and geographic distribution of breast cancer patients in Canada

Cited by 25 publications

References 36 publications

Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Incidence of acute myeloid leukemia: A regional analysis of Canada

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