Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profiles1

DeFina, Rachel; Liang, Yurong; He, Hongzhen; Haley, Kathleen J.; Christopher, Kenneth B.; Perkins, David L.

doi:10.1097/01.tp.0000113803.45613.f8

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…This theory is further supported by (1) IL-17 being preferentially produced by ␥␦ T cells rather than CD4 ϩ and CD8 ϩ T cells; and (2) ␥␦ T cell-deficient recipient mice showing prolonged cardiac allograft survival compared with controls. 41 In addition to CD4 ϩ and CD8 ϩ T cells, several lines of evidence show that ␥␦ T cell-derived IL-17 plays pathogenic roles in various diseases such as infectious and autoimmune diseases. [42][43][44][45] As well, ␥␦ T cell-derived IL-17 has been shown to participate in the pathogenesis of ischemia-reperfusion injury in the brain.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion

et al. 2011

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Background-Interleukin-17 , which is predominantly produced by T helper 17 cells distinct from T helper 1 or T helper 2 cells, participates in the pathogenesis of infectious, autoimmune, and allergic disorders. However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice. Methods and Results-Donor hearts from FVB mice were heterotopically transplanted into either C57BL/6J-IL-17-deficient (IL-17

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Section: Discussionmentioning

confidence: 99%

Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion

et al. 2011

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“…Previous studies indicated that cd T cell showing protective functions in human kidney and liver graft [4,5]. Also, some investigators reported that cd T cell contributed to development of transplant rejection [6,7]. Our previous study showed that cd T cells represented a dominant IL-17-producing lymphocyte subset in cardiac transplantation [8].…”

Section: Introductionmentioning

confidence: 91%

γδ T Cell Receptor Deficiency Attenuated Cardiac Allograft Vasculopathy and Promoted Regulatory T cell Expansion

Zhu

Wang

et al. 2013

Scand J Immunol

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Abstractcd T cell comprises about 5% of the overall T cell population, and they differ from conventional ab T cells. Previous studies have indicated the contribution of cd T cell to acute allograft rejection, but the role of cd T cell in cardiac allograft vasculopathy (CAV) is not investigated. Hearts of adult B6.C-H-2 bm12 KhEg were heterotopically transplanted into major histocompatibility complex (MHC) class II-mismatched C57BL/6 mice (wild-type, cd TCR À/À ), which is an established murine model of chronic allograft rejection without immunosuppression. The survival of grafts was monitored daily by abdominal palpation until the complete cessation of cardiac contractility. Our current study demonstrated that cd T cell receptor (TCR) deficiency significantly attenuated CAV, and this effect coincides with low expression of Hmgb1, IFN-c and IL-17 while increased number of CD4 + CD25 + Foxp3 + regulatory T cells, and depletion of regulatory T cells abrogated the prolonged allograft survival induced by cd TCR deficiency. cd TCR deficiency resulted in attenuated CAV and prolonged graft survival in murine models of cardiac transplantation, and this effect was associated with enhanced expansion of regulatory T cells.

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Microarray Analysis of Gene Expression in Murine Cardiac Graft Infiltrating Cells

Liang

Lü

Perkins

2007

Methods in Molecular Biology

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Microarray technology can rapidly generate large databases of gene expression profiles. Our laboratory has applied these techniques to analyze differential gene expression in cardiac tissue and cells based on mouse heart transplantation. We have analyzed the different gene expression profiles such as stress or injury including ischemia following transplantation. We also have investigated the role of infiltrating inflammatory cells during graft rejection by purifying subsets of infiltrating cells using GFP transgenic mice and detailed all technical experiences and issues. The purpose of this study is to assist researchers to simplify the process of analyzing large database using microarray technology.

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Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profiles1

Cited by 6 publications

References 12 publications

Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion

Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion

γδ T Cell Receptor Deficiency Attenuated Cardiac Allograft Vasculopathy and Promoted Regulatory T cell Expansion

Microarray Analysis of Gene Expression in Murine Cardiac Graft Infiltrating Cells

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