2024
DOI: 10.21203/rs.3.rs-3827112/v1
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Analysis of Immune Cell Infiltration Characteristics in Severe Acute Pancreatitis through Integrated Bioinformatics

Rui Chen,
Shuai Xiao,
Han Xiao
et al.

Abstract: Objective: The etiopathogenesisof severe acute pancreatitis(SAP) remains poorly understood.We aim to investigate the role of immune cells Infiltration Characteristics during SAP progression. Methods/Design:Gene expression profiles of the GSE194331 dataset were retrieved from the GEO. Lasso regression and random forest algorithms were employed to select feature genes from genes related to SAP progression and immune responses. CIBERSORT was utilized to estimate differences in immune cell types and proportions an… Show more

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