Analysis of IL10 haplotypes in primary Sjögren’s syndrome patients from Western Mexico: Relationship with mRNA expression, IL-10 soluble levels, and autoantibodies

Vázquez-Villamar, Mirna; Palafox‐Sánchez, Claudia Azucena; Muñoz-Valle, J.F.; Valle, Yeminia; Orozco‐Barocio, Gerardo; Hernández‐Bello, Jorge; Edith, Oregon-Romero

doi:10.1016/j.humimm.2015.06.009

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…The low frequency of anti‐Ro and anti‐La antibodies in pSS patients (24.5% and 13.2%, respectively) have been previously reported by our group and by others . It is possible that the low frequency of anti‐Ro/anti‐La antibodies could be a hallmark of some pSS patient as has been demonstrated in the Mexican population and in the French cohort . This finding confirms the relevance of the histopathology in the classification criteria for pSS, especially in patients with low frequency of anti‐Ro antibodies (in our patients 98.2% and 24.5%, respectively).…”

Section: Discussionsupporting

confidence: 90%

“…In addition, the presence of CD28 and CTLA4 polymorphisms and their haplotypes, did not show the difference in clinical characteristics of pSS patients. The low frequency of anti‐Ro and anti‐La antibodies in pSS patients (24.5% and 13.2%, respectively) have been previously reported by our group and by others . It is possible that the low frequency of anti‐Ro/anti‐La antibodies could be a hallmark of some pSS patient as has been demonstrated in the Mexican population and in the French cohort .…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren′s syndrome in Mexican population

López-Villalobos

Carrillo-Ballesteros

Muñoz‐Valle

et al. 2018

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 78%

Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren′s syndrome in Mexican population

López-Villalobos

Carrillo-Ballesteros

Muñoz‐Valle

et al. 2018

Clinical Laboratory Analysis

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“…We did not observe differences between alleles and haplotypes in terms of the mRNA expression and serum concentration of IL-10. Similar results were observed by Vázquez-Villamar, who found that in primary Sjögren's syndrome, patients showed high serum IL-10 levels and mRNA expression; however, no difference was observed between haplotypes [36]. It was suggested that IL-10 expression is controlled on the transcriptional and post-transcriptional levels.…”

Section: Discussionsupporting

confidence: 83%

The Impact of the IL-10 Gene Polymorphism on mRNA Expression and IL-10 Serum Concentration in Polish Lupus Patients

Żak-Gołąb,

Cieślik,

Siekiera

et al. 2024

IJMS

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies against a lot of nuclear components. Despite many studies on the genetic background of this disease, the pathogenesis remains unclear. The aim of the study is to comprehensively evaluate the polymorphism of the IL-10 promoter gene, its mRNA expression, and the serum IL-10 concentration of SLE female patients and females age-matched controls. Analyzing the association between the level of the tested cytokine and the polymorphism genotype-1082; -819; -592, we found statistically higher serum IL-10 levels in SLE patients compared to in healthy controls (11.9 ± 2.2 pg/mL vs. 9.4 ± 1.7 pg/mL, accordingly; p < 0.0001). We did not find statistically significant differences in the gene polymorphism of IL-10 among SLE patients and controls. The most significant observation derived from our study is that IL-10 mRNA transcripts are upregulated in SLE patients compared to in healthy controls (p < 0.0001). According to our results, the presence of the IL-10 genetic polymorphism has no clinical significance for the development of SLE, and subsequent differences in mRNA and IL-10 concentration results from the influence of other factors which should be the subject of further research.

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“…IL10 gene polymorphisms (‐1082A>G, ‐819C>T, and ‐592C>A) have also been evaluated as risk markers to other inflammatory diseases in population from Western Mexico but similar to our results, they have not found a statistically significant association between these markers and disease susceptibility; however, ATC haplotype was associated with systemic lupus erythematosus (SLE) susceptibility, which is strongly associated with nephropathy . In the present study, we observed that ATC haplotype (‐1082A/‐819T/‐592C) presence, increase 3.6 fold times the risk to DN development [ P = 0.0007; OR = 3.686, 95% CI (1.691‐8.035)], similar to SLE patients.…”

Section: Discussionsupporting

confidence: 83%

IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico

Chavarria-Buenrostro

Hernández‐Bello

Muñoz‐Valle

et al. 2018

Clinical Laboratory Analysis

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Introduction: Diabetic Nephropathy (DN) is the main cause of chronic kidney disease (CKD) in diabetic patients. An IL-10 imbalance could be related to renal hypertrophy and trigger to nephropathy. Three promoter polymorphisms (-1082G>A, -819C>T, and -592C>A) at IL10 gene have been associated with changes in the IL-10 expression and DN susceptibility. Therefore, the aim of this study was to analyze this association in Mexican patients with DN. Methods:We conducted a case-control study on 128 patients with DN and 150 control subjects (CS) from western Mexico. All patients were tested for IL10 polymorphisms by PCR-RFLP. Allele frequencies, genotypes, and haplotypes were compared between groups. The significant haplotypes were correlated with patient clinical features.Results: IL10 gene ATC haplotype (-1082A/-819T/-592C) was found significantly more frequent in DN patients than in CS (P < 0.001; OR = 3.6, 95% CI: 1.7-7.4).Similarly GTA (-1082G/-819T/-592A) haplotype was more frequent in DN patients than CS with significant differences (P < 0.05; OR = 4.02, 95% CI: 1.10-14.78). There were no correlations between IL10 haplotypes and clinical parameters in patients with DN. However, that there is a trend of higher serum urea levels and lower eGFR in ATC haplotype carriers compared to carriers of the other haplotypes (P < 0.05). Conclusions:These results indicate that IL10 promoter haplotypes ATC and GTA carriers have a higher risk factor to develop DN in the western Mexican population. K E Y W O R D S diabetic nephropathy, glomerular filtration rate, haplotype, IL10 haplotypes, IL10 polymorphisms 1 | INTRODUC TI ON Diabetic nephropathy (DN) is a syndrome characterized by the presence of pathological quantities of urine albumin excretion, diabetic glomerular lesions, and loss of glomerular filtration rate (GFR) in diabetic patients. DN patients have structural and functional changes in the kidney, with a mesangial expansion, thickening of the basement membrane, and nodular glomerulosclerosis in the glomeruli. 1,2 All these kidney changes favor the recruitment and activation of immune cells and secretion of pro-inflammatory cytokines. 2 Luz Eliane Chavarria-Buenrostro and Jorge Hernandez-Bello contributed equally to this work.

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Analysis of IL10 haplotypes in primary Sjögren’s syndrome patients from Western Mexico: Relationship with mRNA expression, IL-10 soluble levels, and autoantibodies

Cited by 7 publications

References 64 publications

Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren′s syndrome in Mexican population

Association of CD28 and CTLA4 haplotypes with susceptibility to primary Sjögren′s syndrome in Mexican population

The Impact of the IL-10 Gene Polymorphism on mRNA Expression and IL-10 Serum Concentration in Polish Lupus Patients

IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico

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