1997
DOI: 10.1002/(sici)1097-0320(19970615)30:3<118::aid-cyto2>3.0.co;2-h
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Analysis of IL-2 and IL-6 binding to peripheral blood lymphocytes in Graves disease: Relationship with disease activity

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Cited by 14 publications
(8 citation statements)
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“…Considering its important role in growth and differentiation of lymphocytes, IL-6 might contribute to the promotion of thyroid receptor antibody synthesis during the course of GD [8,24,25]. The observation that the -174C allele and the CC genotype had higher frequencies in our patients is in contrast with a previous study in Polish- Caucasian patients [26].…”
Section: Discussioncontrasting
confidence: 98%
“…Considering its important role in growth and differentiation of lymphocytes, IL-6 might contribute to the promotion of thyroid receptor antibody synthesis during the course of GD [8,24,25]. The observation that the -174C allele and the CC genotype had higher frequencies in our patients is in contrast with a previous study in Polish- Caucasian patients [26].…”
Section: Discussioncontrasting
confidence: 98%
“…Moreover, we have failed to show a relationship between the differences of IL-6/sIL-6R concentrations and the presence of circulating TRAb or TPOAb, suggesting that the activation of the IL-6 system may be independent of thyroid function and of humoral reactions in the thyroid. A correlation between increased numbers of peripheral T-and B-cells binding IL-6, and serum TRAb activity has been found in hyperthyroid untreated GD patients in a recent study (29), suggesting that IL-6 is involved in both the immunological and the hormonal abnormalities of the disease. Heuer et al (30) studied the patterns of cytokine mRNA expression in GD, HT and non-autoimmune disorders and observed mainly quantitative differences, i.e.…”
Section: Discussionmentioning
confidence: 88%
“…CD25 expressions on the peripheral lymphocytes have been reported to increase in patients with various autoimmune disorders (9)(10)(11)14,28,29). In the patients with HD, the proportions of CD3 1 CD25 1 cells increased (12) and the CD25 1 cells were more frequent among the CD4 1 helper T cells (13).…”
Section: Discussionmentioning
confidence: 99%