Abstract:Intermolecular -strands are common in natural protein oligomers; but the pathologic and designed forms triggers the aggregation through the non-native self assembly of misfolded proteins, suggest that natural proteins would be designed to avoid aggregation or misfolding. In particular, self assembly of misfolded proteins is the hallmarks of several neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS etc. Interestingly, interfaces of natural -strand self-assemblies allow accurate definition and the… Show more
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