Analysis of hydroxylated polybrominated diphenyl ethers in rat plasma by using ultra performance liquid chromatography–tandem mass spectrometry

Selective determination of mono- and dihydroxylated analogs of polybrominated diphenyl ethers in marine sponges by liquid-chromatography tandem mass spectrometry

“…This allows the determination of diOHPBDEs in human fluid matrices (e.g., blood). The present LOQ for diOH-BDE68 is slightly higher than the LOQs reported by Mas et al [24] which were measured for eight OH-PBDEs (0.7-4.6 g mL −1 ) in negative ion-spray ionization mode, and also those reported by Lai et al [27] who reported LOQs of 0.2-2.8 ng mL −1 for nine OH-PBDEs, using the same mode. Higher ionization intensities may occur in higher brominated congeners such as penta-BDE or hexa-BDE [32].…”

“…Lupton et al [26] have reported LC/atmospheric pressure chemical ionization (APCI)-MS/MS for OH-PBDEs, ranging from tri-to hexabrominated, in negative APCI mode. Lai et al [27] have developed a robust ultra-performance LC/MS/MS for rapid determination of nine OH-PBDEs to study the pharmacokinetics of 6-OH-BDE47 in ESI mode. We have also developed the simultaneous determination of OH-and MeOPBDEs in APCI mode using both ([M−H] − →Br − ) and ([M −Br+O] − →Br − ) transitions [28].…”

Debrominated, hydroxylated and methoxylated metabolism in maize (Zea mays L.) exposed to lesser polybrominated diphenyl ethers (PBDEs)

“…However, after BDE-15 exposure, the order of de-PBDEs ) MeO-PBDEs > OH-PBDEs was obtained, possibly due to the fact that only limited MeO-PBDE standards are available to date, particularly without MeO-BDE15. The evidence that much lower concentrations of OH-PBDEs than of de-PBDEs or MeO-PBDEs in maize might be attributed to the shorter elimination half-life (Staskal et al, 2005;Kelly et al, 2008;Lai et al, 2011) and as well as less transformation of OH-PBDEs due to their greater toxicity compared with PBDEs and MeO-PBDEs.…”

“…No significant difference in the total concentration of OH-PBDEs in leaves over time was observed between the BDE-15 and -28 exposure. Some studies have shown that the elimination half-life of 6-OH-BDE47 in rat plasma is 71.7-85.6 min (Lai et al, 2011) and much shorter than the half-life of the parent compound [30][31][32][33][34][35][36][37][38][39][40], and 31 d in humans, mice and rats, respectively) (Staskal et al, 2005), and this is likely due to the insignificant accumulation 6-OH-BDE47 in rats. In the present study the total concentration of OH-PBDEs in each part of maize was unlikely to increase significantly with increasing exposure time, and decreased in the BDE-28 and -47 exposed maize roots and stems at the later exposure time.…”

Characterization of polybrominated diphenyl ethers (PBDEs) and hydroxylated and methoxylated PBDEs in soils and plants from an e-waste area, China

“…Mean concentration ratios of P MeO-PBDEs to P OH-PBDEs were 25, 181 and 243 for the soils, plant roots and leaves, respectively. Higher concentrations of P MeO-PBDEs than P OH-PBDEs particularly in plants are likely related to higher accumulation of MeO-PBDEs due to their higher logK ow values than those of the corresponding OH-PBDEs and short elimination half-life of OH-PBDEs (Kelly et al, 2008;Lai et al, 2011;Staskal et al, 2005). Significant positive linear relationships were found between the concentrations of P OH-PBDEs and P MeOPBDEs in the soils, plant roots and leaves (Fig.…”