Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population

Abstract

HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.

Human Papillomavirus Genotypes and HPV16 E6/E7 Variants among Patients with Genital Cancers in Vietnam

“…These results suggest that HPV16 sublineages A1-3 may be more oncogenic than the sublineage A4 in inducing genital cancers in the Vietnamese population. However, these findings are inconsistent with the previous studies that reported the sublineages A4 and D2 were associated with an increased risk of cervical cancer (11, 14), or that found no significant difference in the distribution of HPV16 sublineages A1-3 and A4 between samples from different stages of cervical intraepithelial neoplasia (15). The discrepancy in the oncogenicity of A4 sublineage between this study and others (11,14,15) may be attributed simply to the regional difference in the ethnic groups.…”

“…However, it is noted that the distributions of the HPV16 sublineages A1-3 and A4 in the Vietnamese genital cancer patients (51.5% and 34.8%, respectively) are similar to those found in Chinese cervical cancer patients (54.0% and 45.6%, respectively) (14). In contrast, the distribution of HPV16 sublineages A1-3 and A4 in Vietnamese women with a normal cytology (13.0% and 82.6%, respectively) was the opposite of that in Chinese women with a normal cytology (67.1% and 32.9%, respectively) (14).…”

“…In contrast, the distribution of HPV16 sublineages A1-3 and A4 in Vietnamese women with a normal cytology (13.0% and 82.6%, respectively) was the opposite of that in Chinese women with a normal cytology (67.1% and 32.9%, respectively) (14). Considering that it takes several decades for HPV to develop cancers, these findings suggest a possible chronological change of circulating HPV16 sublineages in Vietnam, such as increasing frequency of sublineage A4 and decreasing frequency of sublineages A1-3.…”

Whole-Genome Analysis of Human Papillomavirus Types 16, 18, and 58 Isolated from Cervical Precancer and Cancer Samples in Chinese Women

“…Compared with women with an HPV16 A1–A3 European lineage infection, women with an HPV16 A4 Asian lineage infection had no significantly increased risk for cervical cancer. However, Hang et al reported that A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women 25 . Thus, further study is required to determine whether A4/Asian variants represent a higher risk for cervical cancer.…”

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

“…Hoje em dia mais de 99% dos cânceres cervicais contêm a presença do HPV e a proporção associada com o tipo do vírus é diferente entre regiões, mostrando variações demográficas, étnicas e sócioeconômicas (CUBIE, 2013), podendo, dessa forma, afirmar que o HPV é um agente necessário para a doença (BAVA et al 2017;HANG et al, 2016).…”