2003
DOI: 10.1016/s0145-2126(02)00228-x
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Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients

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Cited by 37 publications
(29 citation statements)
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“…In addition to its inhibitory function, KIR2DL4 can also have an activating function that may depend on the type of cell. 22 Despite the presence of HLA-G transcription in mature lymphoid cells, HLA-G antigens are not expressed at the cell surface of normal lymphocytes or leukemic cells in the absence of IFN-g. [23][24][25] This finding is at variance with a study published by Nuckel et al 26 showing that a variable percentage of CLL-B cells aberrantly expressed the nonclassical HLA-G molecule. The surface expression of HLA-E depends on the binding of peptides derived from HLA class I molecules.…”
Section: Cell Surface Expression Of Hla Class I Moleculesmentioning
confidence: 68%
“…In addition to its inhibitory function, KIR2DL4 can also have an activating function that may depend on the type of cell. 22 Despite the presence of HLA-G transcription in mature lymphoid cells, HLA-G antigens are not expressed at the cell surface of normal lymphocytes or leukemic cells in the absence of IFN-g. [23][24][25] This finding is at variance with a study published by Nuckel et al 26 showing that a variable percentage of CLL-B cells aberrantly expressed the nonclassical HLA-G molecule. The surface expression of HLA-E depends on the binding of peptides derived from HLA class I molecules.…”
Section: Cell Surface Expression Of Hla Class I Moleculesmentioning
confidence: 68%
“…26,27 HLA-G expression has also been studied in patients with non-Hodgkin lymphoma (NHL). Although one study showed no expression, 28 other studies reported 65%-100% HLA-G expression in B-NHL, 29 and 58% expression in T-NHL. 30 Similar results for MM are now reported in this study.…”
Section: Discussionmentioning
confidence: 88%
“…To date, the expression of HLA-G in hematological malignancies has been investigated in a number of studies [39][40][41][42][43] with conflicting findings, presumably due to the heterogeneity of the studied population or technical factors. Amiot et al 39 investigating HLA-G expression in normal and malignant hematopoiesis found HLA-G transcripts only in T and B lymphocytes and a variable proportion of their malignant counterparts (6/15 ALL, 100% of B-NHLs, 20/30 CLL), no protein antigens were detected at the cell surface or in the cytosol of any of these cells.…”
Section: Discussionmentioning
confidence: 99%
“…40 A retrospective study investigating 51 leukemia samples, including 8 CLL did not detect HLA-G surface expression nor transcripts in CLL. 41 Notably, HLA-G expression has recently been reported in B-CLL and associated with an unfavorable outcome. 42 Flow cytometry analysis of CLL samples (n ¼ 47) showed surface expression of HLA-G in a variable proportion of tumor cells in all CLL samples examined that correlated with survival.…”
Section: Discussionmentioning
confidence: 99%