Analysis of hemocoagulation tests for prediction of venom-induced consumption coagulopathy development after Viperidae bite

Valenta, J; Stach, Zdeněk; Pořízka, Michal; Michálek, Pavel

doi:10.4149/bll_2019_092

Cited by 3 publications

(1 citation statement)

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“… 8 The coagulopathic effects of viper venom result from consumption or inhibition of coagulation factors resulting in widespread bleeding, also known as venom-induced consumption coagulopathy. 7 , 9 , 10 The patient falls into a state of disseminated intravascular coagulation wherein soluble fibrin is produced, causing the appearance of small blood clots scattered in the lumen. The process of fibrinolysis leads to excessive consumption of coagulation factors, tissue ischemia, tissue hypoxia, and bleeding.…”

Section: Introductionmentioning

confidence: 99%

Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tests following viper snakebites

et al. 2022

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Background A high prevalence of venom-induced consumption coagulopathy has been reported in individuals with viper snakebites. Rotational thromboelastometry (ROTEM) is a rapid technique that could be advantageous in assessing and monitoring coagulation disorders. Purpose To explore correlations between ROTEM and standard coagulation tests. Patients and methods This prospective observational study was performed among 41 patients with viper envenomation admitted to the Vietnam Poison Control Center from April 2016 to October 2017. Standard coagulation measurements [platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen level] and ROTEM indicators [clotting time (CT), amplitude (at set time: 5 and 10 minutes), clot information time (CFT) and maximum clot firmness (MCF) for extrinsic (EXTEM), intrinsic (INTEM), and fibrin based (FIBTEM) ROTEM] were obtained. Results For INTEM, EXTEM, the FIBTEM, proportions of patients with prolonged CT were 34.1%, 63.4%, and 61.0% respectively and the proportions of patients with decreased MCF were 62.2%, 62.2%, and 35.5%, respectively. Moderate correlations were observed between PT and EXTEM CT (r = 0.627), aPTT and INTEM CT (r = 0.626), fibrinogen and FIBTEM MCF (r = 0.723), and platelet count and EXTEM MCF (0.60). Conclusion ROTEM indicated a hypocoagulation state in patients with viper snakebite and was moderately correlated with standard coagulation parameters.

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Section: Introductionmentioning

confidence: 99%

Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tests following viper snakebites

et al. 2022

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Echis carinatus snakebite, a rare case of fatal envenomation in a young Pakistani boy: a case report.

Siddiqui,

Siddiqui

2023

Preprint

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Snakebite poses a significant public health concern in the Sindh region of Pakistan,. The Echis carinatus,also known as Saw Scaled Viper (SSV), a venomous snake from the Viperidae family, is one of the species found in the area. It is responsible for a substantial number of the approximately 29,000 snakebites reported annually in the country. We reported the case of a young Pakistani boy, who was bitten by an SSV and developed venom-induced consumptive coagulopathy (VICC) within 24 hours. Additionally, he experienced necrotizing fasciitis at the bite site, which led to systemic septicemia and acute renal failure. Despite receiving the best treatment available, the patient passed away within five days. This case report underscores the importance of early FFP transfusions and prophylactic use of broad-spectrum antibiotics in treating VICC, acute renal failure, and wound infections.

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Fibrinogenolysis in Venom-Induced Consumption Coagulopathy after Viperidae Snakebites: A Pilot Study

Valenta

Hlaváčková

Stach

et al. 2022

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Envenomations that are caused by Viperidae snakebites are mostly accompanied by venom-induced consumption coagulopathy (VICC) with defibrination. The clinical course of VICC is well described; however, reports about its detailed effects in the hemocoagulation systems of patients are sparse. In this pilot study, we prospectively analyzed the changes in plasma fibrinogen that were caused by the envenomation of six patients by five non-European Viperidae snakes. Western blot analysis was employed and fibrinogen fragments were visualized with the use of specific anti-human fibrinogen antibodies. All of the studied subjects experienced hypo- or afibrinogenemia. The western blot analysis demonstrated fibrinogenolysis of the fibrinogen chains in all of the cases. Fibrinogenolysis was considered to be a predominant cause of defibrination in Crotalus, Echis, and Macrovipera envenomation; while, in the cases of VICC that were caused by Atheris and Calloselasma envenomation, the splitting of the fibrinogen chains was present less significantly.

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Analysis of hemocoagulation tests for prediction of venom-induced consumption coagulopathy development after Viperidae bite

Cited by 3 publications

References 9 publications

Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tests following viper snakebites

Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tests following viper snakebites

Echis carinatus snakebite, a rare case of fatal envenomation in a young Pakistani boy: a case report.

Fibrinogenolysis in Venom-Induced Consumption Coagulopathy after Viperidae Snakebites: A Pilot Study

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