Analysis of heart rate variability demonstrates effects of development on vagal modulation of heart rate in healthy children

Goto, Masahiko; Nagashima, Masami; Baba, Reizo; Nagano, Yukiko; Yokota, Mitsuhiro; Nishibata, Kenji; Tsuji, Akinito

doi:10.1016/s0022-3476(97)80013-3

Cited by 103 publications

(97 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infants particularly have a high sympathetic activity that then decreases between ages 5 and 10 years, while the sympatho-vagal balance as expressed by the LF / HF ratio changes less. 12 The age-related decreases in heart rate, CVRR, C-CVHF, and HF power now documented are in accordance with the expectation from smaller, crosssectional studies. 9,[11][12][13] Despite maturation changes, the CVRR and HF results at the two examinations correlated well, although the LF results varied more.…”

Section: Discussionsupporting

confidence: 85%

“…12 The age-related decreases in heart rate, CVRR, C-CVHF, and HF power now documented are in accordance with the expectation from smaller, crosssectional studies. 9,[11][12][13] Despite maturation changes, the CVRR and HF results at the two examinations correlated well, although the LF results varied more. The blood pressure levels and the age-associated increase in systolic blood pressure are in accordance with data from previous cross-sectional studies.…”

Section: Discussionsupporting

confidence: 85%

“…The blood pressure levels and the age-associated increase in systolic blood pressure are in accordance with data from previous cross-sectional studies. 40 Only limited sex-related differences were seen at the two ages examined, while some, 9,12 but not all, 17,21 previous studies reported an HRV difference between small numbers of boys and girls. An increased LF / HF ratio is thought to act as a predictor of increased blood pressure, 10 and the results of the present study support this notion by the significant associations between increased systolic blood pressure and decreases in CVRR and HF results.…”

Section: Discussionmentioning

confidence: 81%

“…[5][6][7][8][9] Sympathetic hyperactivity and parasympathetic hypoactivity have been documented in connection with cardiovascular diseases. 6,10 The CVRR increases with age up to 6-10 years, 11,12 followed by a decrease related to reduced parasympathetic activity. 13 Boys have a greater CVRR than girls, 13 and HRV is increased by physical training.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort

Grandjean

Murata

Budtz‐Jørgensen

et al. 2004

The Journal of Pediatrics

197

131

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

See 2 more Smart Citations

Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort

Grandjean

Murata

Budtz‐Jørgensen

et al. 2004

The Journal of Pediatrics

197

131

View full text Add to dashboard Cite

“…It has been shown that the peak of the high frequency component (HF) was a reflection of the parasympathetic system, whereas the peak of low frequency (LF) depended on the baroreflex and under the influence of the two components of the autonomic nervous system (ANS), sympathetic and parasympathetic. In children, some authors have reported that heart rate variability (HRV) depended on age [7,8]. If remifentanil acts by provoking a stimulation of the parasympathetic ANS, it could then have different haemodynamic effects in children in comparison with adults, particularly in terms of bradycardia.…”

mentioning

confidence: 99%

Effect of remifentanil with and without atropine on heart rate variability and RR interval in children

et al. 2005

View full text Add to dashboard Cite

SummaryRemifentanil can cause bradycardia either by parasympathetic activation or by other negative chronotropic effects. The high frequency (HF) component of heart rate variability (HRV) is a marker of parasympathetic activity. This study aimed to evaluate the effect of remifentanil on RR interval and on HRV in children. Forty children ASA I or II were studied after approval by the human studies committee and informed parental consent was obtained. After stabilisation at sevoflurane 1 MAC, they were randomly divided into two groups: one received a 20 lg.kg atropine injection (AT + REMI) and the other ringer lactate solution (REMI). Three minutes later, a 1 lg.kg )1 bolus of remifentanil was administered over 1 min, followed by a continual infusion at 0.25 lg.kg )1 .min )1 for 10 min increased to 0.5 lg.kg )1 .min )1 for a further 10 min.A time varying, autoregressive analysis of RR sequences was used to estimate classical spectral parameters: low (0.04-0.15 Hz; LF) and high (0.15-0.45 Hz; HF) frequency, whereas the root mean square of successive differences of RR intervals (rmssd) was derived directly from the temporal sequence. Statistical analyses were conducted by means of the multiple correspondence analysis and with non parametrical tests. Remifentanil induced an RR interval lengthening, i.e. bradycardia, in both groups compared to pretreatment values and was associated with an increase of HF and rmssd only for the REMI group. The parasympathetic inhibition by atropine did not totally prevent remifentanil's negative chronotropic effect. A direct negative chronotropic effect of remifentanil is proposed.

show abstract

Is Heart Rate Variability Related to Season of Birth?

Huang

Hwang

Lai

et al. 2015

Clinical Cardiology

View full text Add to dashboard Cite

Background: Season of birth (SOB) has been found to be related to cardiovascular mortality, but the mechanisms are unclear. It is suggested that birth in winter is a protective factor for the circulatory system, and this should be able to be observed using heart rate variability (HRV) measurements. The phenomenon may have a sex difference and is likely to be modulated by climatic factors. This study focused on this problem and investigates healthy school-age children to minimize confounding factors. Hypothesis: Birth in winter is protective to cardiovascular system via autonomic modulation. There is a gender difference in the relationship between SOB and autonomic activity. Climatic factors are the cause of SOB effects on autonomic system. Methods: A total of 381 healthy school-age children were recruited for this study. Their HRV profiles were measured once and climatic information related to their month of birth was gathered. The HRV profiles of the 2 sexes and 4 seasons of birth were compared. Correlation and regression analysis were performed to clarify the relationship between climatic factors and the HRV results. Results: Boys born in winter have higher high-frequency power (HF) but a lower ratio of low-frequency power to high-frequency power (LF/HF) than do males born in other seasons. This result is not found for girls. Age and the temperature of the SOB are predictive factors for HF among boys. The humidity of SOB is a predictive factor for normalized low-frequency power (LF%) and LF/HF among girls. Conclusions: Season of birth is related to both parasympathetic and sympathetic activity among school-age children, especially boys. Temperature and humidity are potential causes of this SOB phenomenon.

show abstract

Analysis of heart rate variability demonstrates effects of development on vagal modulation of heart rate in healthy children

Cited by 103 publications

References 24 publications

Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort

Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort

Effect of remifentanil with and without atropine on heart rate variability and RR interval in children

Is Heart Rate Variability Related to Season of Birth?

Contact Info

Product

Resources

About