Analysis of glucose metabolism of 18F-FDG in major depression patients using PET imaging: Correlation of salivary cortisol and α-amylase

Wei, Kai; Xue, Hao; Guan, Yihui; Zuo, Chuantao; Ge, Jingjie; Zhang, Hongying; Liu, Baojun; Cao, Yuxue; Dong, Jingcheng; Du, Yanqiu

doi:10.1016/j.neulet.2016.06.039

Cited by 14 publications

(14 citation statements)

References 26 publications

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“…Although these findings are similar to those from previous mono-mode studies using ASL or FDG PET (15,16), it is notable that the abnormal cerebral regions demonstrated in the two previous imaging studies did not fully correspond with those in this dual-mode trial. The cerebral hypometabolism in the FDG PET images involved a much wider brain area compared with the cerebral hypoperfusion images.…”

Section: Discussionsupporting

confidence: 74%

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Shi

Gao

et al. 2017

Experimental and Therapeutic Medicine

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The aim of this study was to explore the functions of cerebral blood perfusion and glucose metabolism in the prefrontal lobe of patients with major depression disorder (MDD), and to analyze the correlations between these functional changes and depressive symptoms. 3D-arterial spin labeling (ASL) and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were successfully performed in 17 patients with MDD and 16 healthy controls in a resting state. The depressive symptoms of the patients were classified into seven factors and scored with the Hamilton Depression Rating Scale. Regional cerebral blood flow (CBF) values and standardized uptake values (SUV) of 18F-FDG in the whole brain were respectively compared between the patients and healthy controls using a two-sample t-test, and the correlations between the CBF and SUV in the prefrontal cerebral regions with the patients' Hamilton scores were evaluated using Pearson correlation analysis. Decreased regional CBF was indicated in the bilateral middle and the right superior frontal gyri, and decreased regional SUV was indicated in the bilateral superior, middle and inferior frontal gyri in the MDD patients compared with the controls. Positive correlations were observed between CBF values and aggregate Hamilton scores in the left middle and right middle frontal gyri of the patients. Positive correlations were also observed between SUVs and aggregate Hamilton scores in the left middle and right middle frontal gyri. 18F-FDG PET/CT was indicated to be more sensitive than 3D-ASL in identifying the functional abnormalities in the prefrontal lobe. Decreased CBF and SUV in the prefrontal lobe were closely correlated with Hamilton score. The left middle frontal gyrus may be a key functional region in MDD.

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Section: Discussionsupporting

confidence: 74%

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Shi

Gao

et al. 2017

Experimental and Therapeutic Medicine

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“…Subcortical brain areas – namely, the ventral caudate ( Yang and Wang, 2017 ), the nucleus accumbens (ΝA) ( Gong et al, 2017 ) and the amygdala ( Wei et al, 2016 ) – were used as seed regions to investigate connectivity changes in depressed patients compared to healthy controls (HCs).…”

Section: Resultsmentioning

confidence: 99%

Resting-state connectivity studies as a marker of the acute and delayed effects of subanaesthetic ketamine administration in healthy and depressed individuals: A systematic review

Kotoula

Webster²,

Stone

et al. 2021

Brain and Neuroscience Advances

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Acute ketamine administration has been widely used in neuroimaging research to mimic psychosis-like symptoms. Within the last two decades, ketamine has also emerged as a potent, fast-acting antidepressant. The delayed effects of the drug, observed 2–48 h after a single infusion, are associated with marked improvements in depressive symptoms. At the systems’ level, several studies have investigated the acute ketamine effects on brain activity and connectivity; however, several questions remain unanswered around the brain changes that accompany the drug’s antidepressant effects and how these changes relate to the brain areas that appear with altered function and connectivity in depression. This review aims to address some of these questions by focusing on resting-state brain connectivity. We summarise the studies that have examined connectivity changes in treatment-naïve, depressed individuals and those studies that have looked at the acute and delayed effects of ketamine in healthy and depressed volunteers. We conclude that brain areas that are important for emotional regulation and reward processing appear with altered connectivity in depression whereas the default mode network presents with increased connectivity in depressed individuals compared to healthy controls. This finding, however, is not as prominent as the literature often assumes. Acute ketamine administration causes an increase in brain connectivity in healthy volunteers. The delayed effects of ketamine on brain connectivity vary in direction and appear to be consistent with the drug normalising the changes observed in depression. The limited number of studies however, as well as the different approaches for resting-state connectivity analysis make it very difficult to draw firm conclusions and highlight the importance of data sharing and larger future studies.

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“…Tracer uptake was calculated in several predefined volumes-of-interest (VOI). VOIs were selected based on previous findings, 22,23,45–51 taking the size of the brain regions into consideration. Due to the limited resolution of the small animal PET scanner (1.4 mm), 52 small brain regions were excluded to minimize partial volume effects.…”

Section: Methodsmentioning

confidence: 99%

Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study

Feltes

Vries

Juárez-Orozco

et al. 2017

J Cereb Blood Flow Metab

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Psychosocial stress is a risk factor for the development of depression. Recent evidence suggests that glial activation could contribute to the development of depressive-like behaviour. This study aimed to evaluate in vivo whether repeated social defeat (RSD) induces short-and long-term inflammatory and metabolic alterations in the brain through positron emission tomography (PET). Male Wistar rats (n ¼ 40) were exposed to RSD by dominant Long-Evans rats on five consecutive days. Behavioural and biochemical alterations were assessed at baseline, day 5/6 and day 24/25 after the RSD protocol. Glial activation ( 11 C-PK11195 PET) and changes in brain metabolism ( 18 F-FDG PET) were evaluated on day 6, 11 and 25 (short-term), and at 3 and 6 months (long-term). Defeated rats showed transient depressive-and anxietylike behaviour, increased corticosterone and brain IL-1b levels, as well as glial activation and brain hypometabolism in the first month after RSD. During the third-and six-month follow-up, no between-group differences in any investigated parameter were found. Therefore, non-invasive PET imaging demonstrated that RSD induces transient glial activation and reduces brain glucose metabolism in rats. These imaging findings were associated with stress-induced behavioural changes and support the hypothesis that neuroinflammation could be a contributing factor in the development of depression.

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Analysis of glucose metabolism of 18F-FDG in major depression patients using PET imaging: Correlation of salivary cortisol and α-amylase

Cited by 14 publications

References 26 publications

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Resting-state connectivity studies as a marker of the acute and delayed effects of subanaesthetic ketamine administration in healthy and depressed individuals: A systematic review

Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study

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