Analysis of genu and splenium of the corpus callosum: comparison between healthy subjects with and without Leukoaraiosis

Abstract

The purpose of this study to investigate whether there are any differences in Diffusion Tensor Imaging (DTI) values in subjects that have leukoaraiosis (LA) in the frontal white matter (fWM) and occipital white matter (oWM) compared to subjects that have no LA in those areas in the brain. DTI indices namely axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD), fractional anisotropy (FA) were measured via retrospective study. Finding from this study shows that there is no significant difference in AD, RD, MD, and FA values between both groups. It is concluded that there are no significant differences in DTI values of genu and splenium of the corpus callosum between subjects with and without LA. This study shows that subjects with LA does not having degeneration on fiber bundles of the genu and splenium, in which the genu and splenium function in connecting right and left of hemisphere. Also, it might does not affect or not yet affect the genu and splenium fiber bundles. This finding the differences is important to determine whether any changes in AD and RD values.