Analysis of genetic structure in Slovak Pinzgau cattle using five candidate genes related to milk production traits

Miluchová, Martina; Gábor, Michal; Trakovická, Anna

doi:10.2298/gensr1403865m

Cited by 12 publications

(9 citation statements)

References 18 publications

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“…On the contrary the exotic breeds like HF and Jersey which are recommended for crossbreeding in India had a higher range of A1 allele (0.01 to 0.72) frequency all over the globe (Kaminski et al, 2007). The predominance of A2 allele was identified in Carora cattle population (Caroli et al, 2009); Simmental breed and Holstein breed (Miluchova et al, 2014).…”

Section: Resultsmentioning

confidence: 93%

A Study on β-Casein Gene Polymorphism in Crossbred Cattle and Murrah / Graded Murrah Buffalo in Tamil Nadu

Kathiravan

Malarmathi

et al. 2021

IJAR

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Background: Majority of the people believed that, only the native breeds have A2 milk than exotic or crossbred animals. There is no enough research on milk protein variants have been carried out in Indian zebu cattle. Present study was conducted to screen more number of crossbred cattles and buffaloes in Tamil Nadu to identify the frequency of A1 and A2 alleles in the population.Methods: The study was conducted on 68 cattle and 172 murrah / graded murrah buffaloes to explore the polymorphic variants of β-casein gene. Genomic DNA was extracted by phenol-chloroform method. Polymerase Chain Reaction (PCR) was performed with allele specific primers to amplify a 244 bp long fragment of beta-casein gene and visualized in 2% agarose gel electrophoresis. The population genetic indices were calculated based on the formulas.Result: In the present study revealed higher level of A2A2 genotype frequency (1.00) and fixation of A2 allele in kangayam cattle and murrah / graded murrah buffalo. The observed frequency of A1A1, A1A2 and A2A2 genotypes were 0.38,0.62 and 0.00 for jersey crossbred and 0.29, 0.71 and 0.00 for HF crossbred cattle. The range of Expected homozygosity (0.50 to 1.00), polymorphism information content (0.30 to 0.38), effective number of alleles (1.00 to 2.00) and level of possible variability realization value (44.54% to 100%) reflected existence of medium genetic variability in studied population.

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Section: Resultsmentioning

confidence: 93%

A Study on β-Casein Gene Polymorphism in Crossbred Cattle and Murrah / Graded Murrah Buffalo in Tamil Nadu

Kathiravan

Malarmathi

et al. 2021

IJAR

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“…Change of breeding goal to preserve the dual purpose character of Slovak Pinzgau is proposed, with an expected positive impact on the population structure (Kasarda et al, 2014). Polymorphism of genes encoding leptin, leptin receptor (Trakovická et al, 2013) and five others candidate genes associated with production parameters (Miluchová et al, 2014) a routine collection of genomic information provides an invaluable tool for effective management of breeding programs in small, endangered populations (Mészáros et al, 2015). The main objective of this study was to provide a detailed insight into genomic characterisation of the Pinzgau cattle (Slovak and Austrian Pinzgau) by utilizing high-throughput molecular information.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of local cattle*

et al. 2018

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The Slovak Pinzgau breed faces the bottleneck effect and the loss of diversity due to unequal use of founders and a significant population decline. Further population size reduction can lead to serious problems. Information obtained here and in other studies from high-throughput genotyping of 179 individuals was used to characterise genetic diversity and differentiation of Slovak Pinzgau, Austrian Pinzgau, Cika and Piedmontese cattle by Bayesian clustering algorithm. A gene flow network for the clusters estimated from admixture results was produced. The low estimate of genetic differentiation (F) in Pinzgau cattle populations indicated that differentiation among these populations is low, particularly owing to a common historical origin and high gene flow. Changes in the log marginal likelihood indicated Austrian Pinzgau as the most similar breed to Slovak Pinzgau. All populations except the Piedmontese one displayed two ways of gene flow among populations, indicating that Piedmontese cattle was involved in producing of the analysed breeds while these breeds were not involved in creation of Piedmontese. Genetic evaluation represents an important tool in breeding and cattle selection. It is more strategically important than ever to preserve as much of the livestock diversity as possible, to ensure a prompt and proper response to the needs of future generations. Information provided by the fine-scale genetic characterization of this study clearly shows that there is a difference in genetic composition of Slovak and Austrian populations, as well as the Cika and Piedmontese cattle. Despite its population size, the Slovak Pinzgau cattle have a potential to serve as a basic gene reserve of this breed, with European and world-wide importance.

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“…DNA-based techniques like Polymerase Chain Reaction -Restriction Fragment Polymorphism (Miluchova, Gabor, & Trakovicka, 2014), Polymerase Amplification created Restriction site (ul Haq, Kapila, Sharma, Saliganti, & Kapila, 2014), and Single-Stranded Conformational Polymorphism (Barroso, Dunner, & Cañón, 1999) can be used to observe these alleles. In terms of digestive breakdown, A2 is more like a human βcasein than A1 (Barnett et al, 2014).…”

Section: Genetic Variants Of β-Casein (β-Casein Polymorphism)mentioning

confidence: 99%

“…Similarly, Lulu, one of the highland cattle and native breeds of Nepal, also shares a high A2 homozygous genotype . However, the cattle from western countries (Denmark, Slovakia) have either A1 dominant genotype or an equal proportion of A1 and A2 variants of βcasein (Gustavsson et al, 2014;Miluchova et al, 2014). Some of the cattle breeds that have been genotyped across the globe concerning β-casein variants are documented in Table 2.…”

Section: Genotypes Of β-Casein Variants In Different Cattle Breeds Across the Worldmentioning

confidence: 99%

The Global Scenario of A1, A2 β-Casein Variant in Cattle and its Impact on Human Health

Gorkhali

Sherpa

Koirala

et al. 2021

Global J. Ag. Allied Sc.

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Beta casein (β-casein) has gained considerable interest among scientists and farmers as it provides promising factors to milk that enhance its quality and concentration. It is believed that the A1 β-casein variant shares an association with numerous human diseases. Since there are numerous hypotheses concerning the link between variants of β-casein and human diseases, many researchers across the globe have genotyped the cattle in terms of A1, A2 β-casein variants. This paper catalogs the A1 and A2 β-casein genotypes shared by different cattle breeds across the globe. Various literature encompassing the adverse effects of β-casein variants were assessed adequately. This paper suggests that the effects of undertaking the A1 β-casein variant on human health are ambiguous. Adequate research providing stronger evidence is needed for understanding the effects imparted by the consumption of both A1 and A2 β-casein variants on human health.

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Analysis of genetic structure in Slovak Pinzgau cattle using five candidate genes related to milk production traits

Cited by 12 publications

References 18 publications

A Study on β-Casein Gene Polymorphism in Crossbred Cattle and Murrah / Graded Murrah Buffalo in Tamil Nadu

A Study on β-Casein Gene Polymorphism in Crossbred Cattle and Murrah / Graded Murrah Buffalo in Tamil Nadu

Genetic diversity of local cattle*

The Global Scenario of A1, A2 β-Casein Variant in Cattle and its Impact on Human Health

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