Analysis of genetic polymorphisms and environmental risk factors related to sarcopenia combined with atherosclerosis by means of magnetic nanoparticles

Abstract

Sarcopenia is an aging syndrome characterized by decreased muscle function and skeletal muscle strength or quality. It is often accompanied by atherosclerosis (AS), which poses a great threat to the health and quality of life of the elderly. However, the relationship between sarcopenia and AS is poorly understood, so the clinical establishment of preventive measures for sarcopenia combined with AS requires further investigation. This paper aims to explore the genetic and environmental risk factors of sarcopenia complicated with AS. The clinical data of 252 non-blood-related patients with sarcopenia admitted to our hospital from May 2016 to May 2020 were retrospectively analyzed and allocated to AS and non-AS groups basing on whether they had concurrent AS. Univariate analysis found statistically significant (P <0.05) differences between the two groups’ vitamin D receptor (VDR) FokI loci genotypes and alleles, XbaI XX loci genotypes and alleles, ages, family history of AS, merge inflammation, growth hormone (GH) levels, insulin-like growth factor 1 (IGF-1) levels, testosterone levels, estrogen levels, insulin resistance (IR), vitamin D deficiency, and bone density. A multivariable logistic regression analysis showed VDR FokI loci genotypes and alleles, XbaI XX loci genotypes and alleles, merge inflammation, GH levels, IGF-1 levels, low testosterone levels, low estrogen levels, and vitamin D deficiency were independent risk factors of sarcopenia combined with AS. Therefore, corresponding preventive measures should be taken for the above risk factors in clinical practice to reduce the incidence of sarcopenia combined with AS.