1999
DOI: 10.1093/jat/23.5.301
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Analysis of Gamma-Hydroxybutyrate (GHB) in Urine by Gas Chromatography-Mass Spectrometry

Abstract: A simple method for the direct analysis of gamma-hydroxybutyrate (GHB) from human urine is described. The method uses solid-phase extraction, liquid-liquid extraction, and silyl-derivatization, then gas chromatographic-mass spectrometric analysis using GHB-d6 as the internal standard. The method was linear from 5 to 500 mg/L, and coefficients of variation were less than 10%. Twenty-six urine specimens previously analyzed by an existing method were analyzed and yielded GHB concentrations ranging from 0 to 6100 … Show more

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Cited by 72 publications
(25 citation statements)
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“…Other drugs that have been implicated in sexual assault include γ-hydroxybutyrate (GHB) [5,19,20] and related compounds which are converted to GHB such as γ-butyro- [5,15] (Fig. 4), scopolamine, barbiturates, muscle relaxants such as carisoprodol, cyclobenzaprine, and meprobamate, diphenhydramine, clonazepam, and occasionally other benzodiazepines [5].…”
Section: Drug-facilitated Sexual Assaultmentioning
confidence: 99%
“…Other drugs that have been implicated in sexual assault include γ-hydroxybutyrate (GHB) [5,19,20] and related compounds which are converted to GHB such as γ-butyro- [5,15] (Fig. 4), scopolamine, barbiturates, muscle relaxants such as carisoprodol, cyclobenzaprine, and meprobamate, diphenhydramine, clonazepam, and occasionally other benzodiazepines [5].…”
Section: Drug-facilitated Sexual Assaultmentioning
confidence: 99%
“…As a result of its strong sedative and amnesiac effects, GHB and its analogs have been implicated in a number of DFSA cases [14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…Une autre alternative consiste à faire une extraction du GHB puis à procéder à son dosage par CG ou CG-SM après dérivation (25,26). Récemment, une méthode CG-SM qui combine une extraction en phase solide et une extraction liquideliquide a été décrite (27).…”
Section: Kétamineunclassified