The aerospace industry stands at the forefront of technological advancements, seeking innovative solutions to enhance safety, efficiency, and sustainability. This chapter explores the synergies between artificial intelligence (AI) and blockchain technologies, presenting optimization techniques that promise transformative impacts on aerospace engineering practices. The integration of AI algorithms in aerospace operations spans autonomous systems, predictive maintenance, design optimization, and crew support. Autonomous navigation and control benefit from AI's adaptive decision-making, while predictive maintenance algorithms revolutionize aircraft component upkeep, reducing downtime and operational costs. Furthermore, AI-driven design optimization refines aerodynamics and fuel efficiency, ushering in a new era of aircraft performance. This chapter highlights real-world examples that underscore the importance of data integrity in aerospace, showcasing instances where accurate information is critical for mission success.