Analysis of fouling mechanisms and membrane cleaning during ultrafiltration of bee venom

Silva, Rafael Isidoro da; Brandão, Evelin Campos Verdolin; Brito, Júlio César Moreira; Figueiredo, Kátia Cecília de Souza

doi:10.1080/01496395.2019.1577455

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Flux decline (FD), reversible flux decline (RFD) due to concentration polarization, and irreversible flux decline (IFD) caused by fouling/pore blockage were quantified by using Eqs. 4, 5, and 6, respectively 39

italicFD = ((), \frac{J_{italicAi} - J_{italicAS}}{J_{Ai}}) . 100

italicRDF = ((), \frac{J_{italicWC} - J_{italicAS}}{J_{Ai}}) . 100

italicIDF = ((), \frac{J_{italicAi} - J_{italicWC}}{J_{Ai}}) . 100

where J Ai , J AS , and J WC represent the water flux before each test, the final flux of apitoxin solution, and the flux after membrane cleaning with water.…”

Section: Methodsmentioning

confidence: 99%

Melittin recovery with efficient phospholipase A2 removal of apitoxin from cross‐flow ultrafiltration process

Brandão

Silva

Brito

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND Bee venom (apitoxin) is a complex mixture of enzymes, peptides, amines, and other chemicals that presents diverse pharmaceutical activities. Melittin, a small peptide with 2.84 kDa, represents about 50% of this venom, on a dry basis. However, allergenic compounds, such as phospholipase A2 and hyaluronidase (enzymes with a molecular weight of 19 and 38 kDa, respectively), impair the direct use of apitoxin. The membrane separation process can be considered a potential approach for the fractionation of those components. Therefore, the cross‐flow ultrafiltration with a 10 kDa regenerated cellulose membrane was used to separate melittin from apitoxin, leading to lower fouling in the membrane. RESULTS The strategy was divided into two steps: a 22 factorial design was conducted to evaluate apitoxin concentration and transmembrane pressure, followed by the study of flux decline and fouling mechanisms using the modified Hermia model. The best experimental condition led to 70% of melittin recovery and 99% of rejection of phospholipase A2. Membrane cleaning depicted a recovery of around 92% of flux and reduced 94% of transport resistance. The fouling mechanism revealed three mechanisms acting together in the process. CONCLUSION The results show significant values regarding the recovery of melittin and the removal of phospholipase A2, indicating that the cross‐flow ultrafiltration of apitoxin is an attractive option for the isolation of melittin, which has a high market value. © 2020 Society of Chemical Industry (SCI)

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italicFD = ((), \frac{J_{italicAi} - J_{italicAS}}{J_{Ai}}) . 100

italicRDF = ((), \frac{J_{italicWC} - J_{italicAS}}{J_{Ai}}) . 100

italicIDF = ((), \frac{J_{italicAi} - J_{italicWC}}{J_{Ai}}) . 100

where J Ai , J AS , and J WC represent the water flux before each test, the final flux of apitoxin solution, and the flux after membrane cleaning with water.…”

Section: Methodsmentioning

confidence: 99%

Melittin recovery with efficient phospholipase A2 removal of apitoxin from cross‐flow ultrafiltration process

Brandão

Silva

Brito

et al. 2020

J of Chemical Tech & Biotech

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“…The study also included the analysis of a dynamic model for permeate flux decline and resistance due to membrane fouling (fouling resistance). The mathematical modelling used to verify the experimental results was based on a pore blocking model for tangential filtration adapted from Hermia's dead-end filtration laws Ohanessian et al, 2020;Silva et al, 2020; and the resistance-in-series model at constant pressure .…”

Section: Reuse In Recycled Paper Manufacturingmentioning

confidence: 99%

Optimization of Operation Parameters in Ultrafiltration by Experiment Design, Mathematical Modelling and Fouling Characterization of the Membranes Used to Remove Dissolved and Colloidal Substances from a Treated Paper Mill Effluent

Sousa¹,

Rannany²

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“…Hermia's models were used to predict the fouling mechanisms during cross-flow ultrafiltration (UF) (169) of BV in a 10 kDa regenerated cellulose membrane (170,171).…”

Section: Collection and Membrane Ultrafiltration Of Bvmentioning

confidence: 99%

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Analysis of fouling mechanisms and membrane cleaning during ultrafiltration of bee venom

Cited by 6 publications

References 22 publications

Melittin recovery with efficient phospholipase A2 removal of apitoxin from cross‐flow ultrafiltration process

Melittin recovery with efficient phospholipase A2 removal of apitoxin from cross‐flow ultrafiltration process

Optimization of Operation Parameters in Ultrafiltration by Experiment Design, Mathematical Modelling and Fouling Characterization of the Membranes Used to Remove Dissolved and Colloidal Substances from a Treated Paper Mill Effluent

Data_Sheet_1.docx

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