Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Prieto, Laura; Quesada, Juan F.; Cambero, Olivia; Pacheco, A.; Pellicer, António; Codoceo, Rosa; Garcia-Velasco, Juan A.

doi:10.1016/j.fertnstert.2012.03.052

Cited by 147 publications

(123 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, our findings support earlier studies on infertility in women with endometriosis (37,38), excluding a possible direct effect of ectopically produced AMH on ovarian reserve of women with endometriosis.…”

Section: Discussionsupporting

confidence: 91%

Increased expression of antimüllerian hormone and its receptor in endometriosis

Carrarelli

Rocha

Belmonte

et al. 2014

Fertility and Sterility

View full text Add to dashboard Cite

Objective: To evaluate antim€ ullerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. Design: Prospective study. Setting: University hospitals in Italy and Brazil. Patients: Patients with endometriosis (n ¼ 55) and healthy women (n ¼ 45). Interventions: Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n ¼ 29) or of deep endometriosis (n ¼ 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n ¼ 23) and healthy control subjects (n ¼ 20). Main Outcome Measure(s): AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA. Result(s): Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found. Conclusion(s):The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis.

show abstract

Section: Discussionsupporting

confidence: 91%

Increased expression of antimüllerian hormone and its receptor in endometriosis

Carrarelli

Rocha

Belmonte

et al. 2014

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…In a study by Chattopadhayay et al, increased MDA concentrations, as an index of lipid peroxidation were observed [29]. In contrast to this study, Prieto et al found no difference between women with endometriosis compared with control group [30]. In our study, women undergoing IVF had higher levels of serum MDA, but lower levels of FF MDA than those of controls.…”

Section: Discussioncontrasting

confidence: 69%

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

Pekel

Gönenç

Turhan

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. Methods This study included 109 patients. Patients were classified as unexplained infertility (N=31), PCOS (N=19), tubal factor (N=9) and endometriosis (N=10) and compared with male factor infertility (N=40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Results Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p<0.01, p<0.05, p<0.05). However, SOD activity in unexplained infertility, PCOS and endometriosisgroupswere significantly higher than control group (p<0.01).Decreased follicular fluid TAC levels were found in all patient groups compared with controls (respectively, p<0.01, p<0.05, p<0.01, p<0.01).Patients with tubal factor had significantly higher serum sFasL (p<0.05), but lower follicular fluid sFasL levels (p<0.05) compared with unexplained infertility. Tubal factor and endometriosis groups had lowerfollicular fluid TAC levels compared to unexplained infertility and PCOSgroups (p<0.01). Conclusion(s) In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in infertility, possibly implying increased apoptosis. Especially in unexplained infertility group changes in this parametres more remarkable.

show abstract

“…Some studies suggest that infertility as a result of endometriosis is caused mainly by an impaired ovarian reserve and reduced ovarian response, as indicated by lower anti‐Müllerian hormone, higher FSH, and the aberrant expression of some proteins 10, 11. Several retrospective studies have reported on poor responses to FSH/hMG in patients with endometriosis 12, 13.…”

Section: Discussionmentioning

confidence: 99%

Analyzing the risk factors for a diminished oocyte retrieval rate under controlled ovarian stimulation

Nakamura

Yamashita

Hayashi

et al. 2016

Reprod Medicine & Biology

View full text Add to dashboard Cite

AimTo investigate which risk factors contribute to a lower oocyte retrieval ratio in women who are receiving controlled ovarian hyperstimulation.MethodsThe authors retrospectively analyzed 329 in vitro fertilization (IVF) cycles under controlled ovarian hyperstimulation by using a gonadotropin‐releasing hormone antagonist or agonist at Osaka Medical College, Japan. The patients were classified into five groups: advanced age, male infertility, severe endometriosis, tubal infertility, and unexplained infertility. The primary outcomes were the patients’ age, oocyte retrieval ratio, serum basal follicle‐stimulating hormone, total dose of gonadotropin, and the clinical outcome. A secondary outcome was the stepwise multivariate logistic regression analysis to assess the factors associated with the failure of oocyte retrieval.ResultsThe oocyte retrieval ratio declined significantly with the patient's age. The ratio of endometriosis in unsuccessful cases was significantly higher than that in successful cycles. Advanced age and endometriosis were the factors that were significantly associated with a lowered oocyte retrieval rate.ConclusionAdvanced age and endometriosis are high‐risk factors that contribute to oocyte retrieval failure in infertile patients who are receiving IVF treatment.

show abstract

Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Cited by 147 publications

References 29 publications

Increased expression of antimüllerian hormone and its receptor in endometriosis

Increased expression of antimüllerian hormone and its receptor in endometriosis

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

Analyzing the risk factors for a diminished oocyte retrieval rate under controlled ovarian stimulation

Contact Info

Product

Resources

About