2005
DOI: 10.1002/bmc.561
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Analysis of five HMG‐CoA reductase inhibitors— atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies

Abstract: A specific, accurate, precise and reproducible high-performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous quantitation of five 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, viz. atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin, in pharmaceutical formulations and extended the application to in vitro metabolism studies of these statins. Ternary gradient elution at a flow rate of 1 mL/min was employed on an Intertisl ODS 3V colu… Show more

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Cited by 92 publications
(48 citation statements)
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“…Far to our knowledge first HPLC-PDA method for simultaneous analysis of atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin was reported for determination in pharmaceutical formulations and in vitro metabolism studies [121]. An uncommon gradient method using 3 mobile phase reservoirs was employed.…”
Section: Simultaneous Analysis Of Statin Drugsmentioning
confidence: 99%
“…Far to our knowledge first HPLC-PDA method for simultaneous analysis of atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin was reported for determination in pharmaceutical formulations and in vitro metabolism studies [121]. An uncommon gradient method using 3 mobile phase reservoirs was employed.…”
Section: Simultaneous Analysis Of Statin Drugsmentioning
confidence: 99%
“…Since plasma concentrations of simvastatin is expected to be between 0.1 and 15 ng/mL [12]. However, method by HPLC-UV is suitable for determining simvastatin in pharmaceutical formulations and preparations [13], but is not suitable for pharmacokinetic study. Therefore, sensitive and selective methods for the determination of simvastatin are required for therapeutic drug level monitoring.…”
Section: Introductionmentioning
confidence: 99%
“…It is synthesized from Asperigillus terreus and is an inactive prodrug that is converted to ß-hydroxylate by the liver (Endo, 1981;Sirtori, 1990). It is highly effective in reducing apolipoprotein-B-containing lipoproteins, especially low-density lipoprotein cholesterol and, to a lesser extent, plasma triglycerides, and may cause a small increase in high-density lipoprotein cholesterol (Tobert, 2003;Pasha et al, 2006).…”
Section: Introductionmentioning
confidence: 99%