Analysis of Fc gamma receptor II (CD32) polymorphism in populations of African and South Asian ancestry reveals east–west geographic gradients of allele frequencies

Carrington, Christine V. F.; Norman, Paul J.; Vaughan, R. W.; Kondeatis, E; Ramdath, D. Dan; Hameed, Kamran; Stephens, Henry A.F.

doi:10.1046/j.1365-2370.2003.00417.x

Cited by 3 publications

(3 citation statements)

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“…13 Several studies have found ethnic variation in distribution of the various FccR genotypes. [16][17][18][19] The Samis in northern Norway are the aboriginal inhabitants of Norway and are ethnically different from the caucasoid Norwegians. 20 Studies have shown that the Sami and Norwegian populations differ in the distribution of immune-related diseases such as multiple sclerosis (MS), 21 atopic disease 22 and ankylosing spondylitis.…”

Section: Introductionmentioning

confidence: 99%

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Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations

et al. 2005

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Summary Receptors for the Fc domain of IgG (FcγR) play a critical role in linking cellular and humoral immunity. The various FcγR genotypes may contribute to differences in infectious and immune‐related diseases in various ethnic populations. The Samis are the aboriginal inhabitants of Norway and Fennoscandinavia and differ ethnically from the Norwegians. The distribution of various immune‐related diseases has been reported to differ between Sami and Norwegians. This is the first study to evaluate the distribution of FcγR polymorphisms in a Sami population. Two hundred Samis were genotyped for polymorphisms in the FcγRIIA, FcγRIIIA and FcγRIIIB genes. The genotype and allele frequencies were compared with those of 272 healthy Norwegians. The Sami and Norwegian FcγRIIA, FcγRIIIA and FcγRIIIB genotypes differed significantly. The Samis had higher frequencies of the FcγRIIa‐H/H131, FcγRIIIa‐F/F158 and FcγRIIIb‐NA1/NA1 genotypes. The FcγR genotypes were non‐randomly distributed in both populations. These findings may be important for the prevalence of autoimmune and infectious diseases in the two populations.

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Section: Introductionmentioning

confidence: 99%

“…Several studies have found ethnic variation in distribution of the various FcγR genotypes 16–19 . The Samis in northern Norway are the aboriginal inhabitants of Norway and are ethnically different from the caucasoid Norwegians 20 .…”

Section: Introductionmentioning

confidence: 99%

Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations

et al. 2005

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“…In contrast, there is a dearth in biological anthropology work among Indo-Caribbean groups. Indeed, we could find only a few citations on the population genetics of Indo-Caribbean groups (Carrington et al, 2002(Carrington et al, , 2003.…”

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Indentured migration and differential gender gene flow: The origin and evolution of the East‐Indian community of Limón, Costa Rica

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Blell³

et al. 2007

American J Phys Anthropol

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After the emancipation of African slaves in the Caribbean, the labor void left by out-migrating former slaves was filled by in-migrating indentured servants from prepartition India and China. In some areas of the Caribbean such as Trinidad, Suriname, and Guyana, the East-Indian migrants formed large communities. In this article, we report a study based on mtDNA and Y-chromosomal markers of a small East-Indian community from Limón, Costa Rica. The purpose of the project is to determine the place of origin in the Indian subcontinent of the ancestors of our group and the contributions to its gene pool through gene flow by members of other ethnic groups. Both Y-chromosome and mtDNA suggest that the Indo-Costa Ricans descend from migrants primarily from Central India. While both paternal and maternal markers indicate that this group is overwhelmingly of Indian origin, they also indicate that males and females of African, European, and Amerindian origin contributed to it differently. We discuss our results in the historical context of the virtual extinction of Amerindian Caribbean groups, the forced migration of African slaves to the Caribbean, and the gene flow between Amerindians, Europeans, East-Indians, and Africans that eventually produced the Caribbean's currently diverse gene pool.

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