Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population

Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer

“…Nonsyndromic cleft lip and/or cleft palate (NSCL/P, OMIM119530) is the most common craniofacial birth defect in humans with a global prevalence ranging from 1:500 to 1:2,500 live births [Dixon et al, 2011], depending of ancestry, geographic residential location, maternal age and prenatal exposures, and socioeconomic status [Mossey and Little, 2002;Vieira, 2008;Martelli et al, 2011]. Although there has been marked progress in identifying environmental and genetic risk factors associated with NSCL/P, its etiology in most of the cases remains unclear [Dixon et al, 2011;Rahimov et al, 2012].…”

Retrospectice analysis of patients who were operated consecutively due to cleft lip palate in the last ten years and Review of association with additional malformations

“…Daha önce farklı ülkelerde yarık dudak ve damakta aile öyküsü etkisi üzerine yapılan çalış-malarda, Çekoslovakya'da %18, Polanya'da %19 ve Brezilya'da %35 olarak farklı oranlarda pozitif aile öyküsü rapor edilmiştir (9)(10)(11) . Çalışmamızda, dudak ve damak yarığı birlikte olan hastalarda %15, yalnızca dudak yarığı veya yalnızca damak yarığı olan hastalarda %10 oranında pozitif aile öyküsü saptandı.…”

“…Ek anomalilerin dudak damak yarıklarına eşlik etme oranlarını incelediğimizde, farklı ırklar arasında eş-lik eden ek anomalilerin çeşidi ve oranı farklılıklar göstermektedir (5)(6)(7)(8)(9)(10)(11)(12)13) . Sullivan (12) , siyah ırkta görülen dudak-damak yarık olgularında diğer etnik gruplara nazaran daha fazla Club foot (çarpık ayak) deformitesi ve polidaktili görüldüğünü rapor etmiştir.…”

Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

“…2 Nonsyndromic cleft lip and/or cleft palate (NSCL/P, OMIM #119530) is the most common craniofacial birth defect in humans, with a global prevalence ranging from 1:500 to 1:2,500 live births, 3 depending on ancestry, geographic residential location, maternal age and prenatal exposures, and socioeconomic status. 4 In recent years, epidemiological evidence has shown the association of cancer with NSCL/P in several populational studies. 5,6,7,8 It has been proposed that cancer and congenital malformations such as NSCL/P may occasionally have a common etiology.…”