Analysis of factors influencing survival in patients with severe acute pancreatitis

Kim, Yeon Ji; Kim, Dae Bum; Chung, Woo Chul; Lee, Ji Min; Youn, Gun Jung; Jung, Yun Hwa; Choi, Sooa; Oh, Jung Hwan

doi:10.1080/00365521.2017.1310291

Cited by 9 publications

(8 citation statements)

References 38 publications

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“…Nutrients 2021, 13, 43 2 of 10 Studies in adults have shown that extremes of nutritional status (both undernutrition and obesity) are associated with adverse clinical outcomes and mortality among patients with AP [15,16]. In a recent meta-analysis, obesity has been recognized as an independent risk factor for organ failure in adults with AP [17].…”

Section: Introductionmentioning

confidence: 99%

Undernutrition and Obesity Are Associated with Adverse Clinical Outcomes in Hospitalized Children and Adolescents with Acute Pancreatitis

et al. 2020

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Background: Adult studies demonstrated that extremes of nutritional status adversely impact clinical outcomes in acute pancreatitis (AP). With rising prevalence of undernutrition/obesity in children, we analyzed the effect of nutritional status on the clinical outcomes in children and adolescents with acute pancreatitis. Methodology: We analyzed the Kids’ Inpatient Database (KID) between 2003 and 2016 to include all patients with a primary diagnosis of AP using specific International Classification of Diseases (ICD) codes. We classified into (1) undernutrition, (2) obesity and (3) control groups, based on ICD codes, and we compared severe acute pancreatitis and healthcare utilization (length of stay and hospitalization costs). Results: Total number of AP admissions was 39,805. The prevalence of severe AP was higher in the undernutrition and obesity groups than the control group (15.7% vs. 5.8% vs. 3.5% respectively, p < 0.001). Multivariate analyses demonstrated that undernutrition and obesity were associated with 2.5 and 1.6 times increased risk of severe AP, p < 0.001. Undernutrition was associated with an additional six days of hospitalization and almost $16,000 in hospitalization costs. Obesity was associated with an additional 0.5 day and almost $2000 in hospitalization costs, p < 0.001. Conclusion: Undernutrition and obesity were associated with greater severity of AP, as well as prolonged hospitalization stay and costs. It is imperative for treating clinicians to be aware of these high-risk groups to tailor management and strive for improved outcomes.

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Section: Introductionmentioning

confidence: 99%

Undernutrition and Obesity Are Associated with Adverse Clinical Outcomes in Hospitalized Children and Adolescents with Acute Pancreatitis

et al. 2020

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“…Most AP are often self-limiting. However, about 20% of cases are clinically severe [2]. Globally, in-hospital mortality rate of patients with severe acute pancreatitis (SAP) are estimated to be 5%-42% [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Yang

Qi²,

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The red peony root derived from Paeonia lactiflora has been applied to treat human inflammatory diseases. To investigate its therapeutic potential in treating moderately severe acute pancreatitis (MSAP), which has been rarely studied, this study was designed as a double-blinded, placebo-controlled, randomized clinical trial. A total of 60 MSAP patients were enrolled and randomly divided into an experimental (n = 30) group and a control group (n = 30), who received a coloclyster of 15 g of red peony root or placebo granules dissolved in 150 mL of water, respectively. The patients’ demographic and clinical characteristics were recorded. The results showed that the experimental group had a shorter remission time of fever (p<0.05) and abdominal pain (p<0.01) and faster resumption of self-defecation (p<0.01) than did the control group. In addition, the coloclyster of red peony root decreased the modified Balthazar CT score as well as the serum interleukin-6 and tumor necrosis factor-alpha levels to a greater extent than did the placebo coloclyster (p<0.05). The remission times for the normalization of white blood cells and percentage of neutrophils and lymphocytes in the experimental group were also significantly shorter than those in the control group (p<0.05). In conclusion, a coloclyster of red peony root could help alleviate the clinical symptoms and shorten the course of MSAP by possibly attenuating systematic inflammation. This trial is registered with 14004664.

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“…The modified criteria have a max score of 10. Five parameters are assessed on admission and the other 5 at the 48-hour mark [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Pericarditis: A Clinical and Therapeutic Update

Gomes¹

2020

OJCR

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Rationale: Acute pancreatitis is an unforeseeable and probably fatal disease that has remarkable morbidity and mortality. Acute pancreatitis is not particularly caused by SARS-CoV-2. Failure to diagnose drug-inducing pancreatitis can be serious. Nowadays, the correlation between COVID-19 and acute pancreatitis is still non-evidenced. Unfortunately, the animal studies of COVID-19 causing acute pancreatitis are defective. Patient Concerns: An elderly, housewife, married, Egyptian female patient was presented with acute pancreatitis with mild COVID-19 pneumonia and chronic hypertension.Diagnosis: Acute pancreatitis with mild COVID pneumonia in previously hypertensive patient with possible drug inducing and pancreatic carcinomas association.

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Analysis of factors influencing survival in patients with severe acute pancreatitis

Cited by 9 publications

References 38 publications

Undernutrition and Obesity Are Associated with Adverse Clinical Outcomes in Hospitalized Children and Adolescents with Acute Pancreatitis

Undernutrition and Obesity Are Associated with Adverse Clinical Outcomes in Hospitalized Children and Adolescents with Acute Pancreatitis

Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double‐Blinded, Placebo‐Controlled, Randomized Clinical Trial

Pericarditis: A Clinical and Therapeutic Update

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