Analysis of factors influencing postoperative drainage time in breast cancer

Abstract

Background: To investigate the related factors affecting the postoperative indwelling time of drainage tubes (hereinafter referred to as drainage time) in breast cancer (BC) and evaluate the effect of pseudomonas aeruginosa-mannose-sensitive hemagglutinin (PA-MSHA) preparation on reducing postoperative drainage time. Methods:The clinical data of 165 BC patients in our hospital, including the postoperative drainage time and occurrence of seroma and related complications (such as fever, incision infection, and flap necrosis) after extubation, were retrospectively analyzed. Univariate, multivariate, and stratified analyses were used to determine the correlations between 15 factors including age, body weight, body mass index (BMI), and PA-MSHA preparation, and the postoperative total drainage volume and drainage time.Results: Age, BMI, and PA-MSHA preparation were independent factors affecting the postoperative drainage volume and drainage time of BC patients. Age and BMI were positively correlated with postoperative drainage volume and drainage time (P≤0.004, P≤0.037). PA-MSHA preparation significantly reduced the postoperative total drainage volume and drainage time (P<0.001), decreased the incidence of seroma after extubation (P=0.024), and did not increase complications (P>0.05).Conclusions: Obese and elderly patients were at a significantly high risk of a high drainage volume and long drainage time. Local treatment with PA-MSHA preparation had the advantages of reducing postoperative drainage volume, reducing drainage time, preventing seroma, and not increasing complications, and was a safe and effective treatment. For BC patients aged over 60 years and with a BMI ≥25, the intraoperative local spraying of wounds with PA-MSHA preparation to reduce postoperative drainage times is a valuable option.

Analysis of risk factors affecting the postoperative drainage after a laparoscopic partial nephrectomy: a retrospective study

“…Inoue et al ( 27 ) found that patients with BMI had a higher total drainage volume and longer time of drainage. Long et al ( 28 ) reported a positive correlation between BMI and time of drainage and total drainage volume, and Lee et al ( 11 ) also reported a significant positive correlation between BMI and drainage time. These above results are supported by that of the present study which identified that higher BMI was significantly associated with higher total drainage volume and longer time of drainage.…”

Perioperative care of nipple-areola complex-sparing mastectomy and one-stage breast reconstruction via endoscopic axillary approach for ductal carcinoma in situ: A case report

“…Postoperative incision infection is a significant cause of failure in patients undergoing breast reconstruction with the implantation of flaps and prostheses. [ 6 ] Both the flap and the prosthesis are alloplastic implants that require a longer time to integrate with tissues, resulting in a longer duration of drainage tube placement compared to simple implantation procedures. [ 7 ] Frequent opening of the drain bottle increases the risk of retrograde infections.…”

“…Proper management of the drainage tube has been demonstrated to be crucial in preventing the formation of hematoma and infections. [ 6 ]…”

PA-MSHA improves prognosis of patients undergoing radical cystectomy: a retrospective cohort study using inverse probability of treatment weighting

“…Several in vitro and in vivo studies have shown that Pseudomonas aeruginosa-mannose-sensitive hemagglutinin (PA-MSHA), a genetically modified and inactivated form of Pseudomonas aeruginosa with mannose-sensitive hemagglutinin, can play an anti-tumor role by promoting cancer cell apoptosis, inhibiting cancer cell proliferation, and activating immune cells and cytotoxic effects ( 13 , 14 ). In addition to its antitumor effects, PA-MSHA has been shown in several studies to treat lymphatic leakage in radical mastectomy ( 15 ), gynecologic malignant tumor surgery ( 16 ) and radical thyroidectomy ( 17 ). Lymphatic leakage is also a common complication after PLND, which may affect the postoperative recovery of patients ( 18 ).…”