Analysis of factors influencing pancreatic β-cell function in Japanese patients with type 2 diabetes: Association with body mass index and duration of diabetic exposure

Increment of C-peptide after glucagon injection determines the progressive nature of Japanese type 2 diabetes: A long-term follow-up study

“…The present study has revealed that clinical characteristics (age, duration of diabetes, BMI, secondary SU failure, diabetic retinopathy, HbA1c) at baseline are not correlated with the annual changes of FCPR, 6MCPR, and ΔCPR. Our findings are not consistent with those of Funakoshi et al [10], who proposed that the duration of diabetes exposure and BMI are major factors in β-cell function in Japanese T2D-patients. Based on evidence from a cross-sectional study, they reported that the time-dependent decline of CPR was steeper in obese subjects than in lean subjects [10].…”

“…Our findings are not consistent with those of Funakoshi et al [10], who proposed that the duration of diabetes exposure and BMI are major factors in β-cell function in Japanese T2D-patients. Based on evidence from a cross-sectional study, they reported that the time-dependent decline of CPR was steeper in obese subjects than in lean subjects [10]. Although FCPR, 6MCPR, and ΔCPR at baseline were negatively correlated with duration of diabetes in the present study (data not shown), BMI and the duration of diabetes exposure were not correlated with the annual changes of FCPR, 6MCPR, and ΔCPR.…”

“…The CPR index (CPI) and secretory unit of islet in transplantation (SUIT) were also measured. CPI was calculated by the formula [100×FCPR (ng/mL)]/ fasting plasma glucose (FPG) (mg/dL) [10]. SUIT index was calculated by the formula [FCPR×1500]/ [FPG-61.7 (mg/dL)] [11].…”

Bariatric and Metabolic Surgery for Asians

“…The recent epidemiological data among urban and semi urban southern Indian populations illustrates the changing scenario (13). In addition, reduced physical activity at work due to mechanization, improved motorized transport and preferences for viewing television and video games to outdoor games during leisure time, have resulted in positive energy balance in most Asian countries (14).…”

Reply to the comment of Wilbrink et al. on Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β‐cell function and the achievement of the HbA1c target 1 year after initiation

“…Importantly, the C‐peptide immunoreactivity index cut‐off value for HbA1c < 7.0% achievement by liraglutide monotherapy and sulfonylurea combination was higher than that of liraglutide/basal combination (1.86 and 1.10, respectively)2, 4. It is widely accepted that β‐cell function progressively declines over time in type 2 diabetes patients, making it difficult to obtain appropriate glycemic control without insulin use5, 6. It is possible that basal insulin co‐administration compensated for the decline in β‐cell function associated with longer type 2 diabetes duration in our study2.…”