Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

Ohmi, Satoko; Ono, Masafumi; Takata, Hiroshi; Hirano, Seiki; Funakoshi, Shogo; Nishi, Yuichi; Yoshimura, K.; Amano, Eri; Terada, Yoshio; Saibara, Toshiji; Fujimoto, Shimpei

doi:10.1186/s13098-017-0264-7

Cited by 10 publications

(6 citation statements)

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“…Indices of insulin secretion [homeostasis model assessment (HOMA)-β and insulinogenic index (IGI)] and insulin sensitivity [Quantitative Insulin Sensitivity Check Index (QUICKI) and the Matsuda index (MI)] were calculated using glucose and immunoreactive insulin (IRI) data from the 75 g OGTT, as previously described [ 12 ]. As indices of insulin secretion, the ratio of the area-under-the-insulin-curve to the area-under-the-glucose-curve during 0–120 min of the OGTT (AUC ins/gluc ), which reflects glucose-induced insulin secretion in not only early phase but also in late phase [ 13 ] and the insulin secretion-sensitivity index-2 (ISSI-2) [ 14 , 15 ], an oral disposition index that reflects the compensatory insulin secretion capacity against decreased insulin sensitivity (increased insulin resistance), were also calculated.…”

Section: Methodsmentioning

confidence: 99%

Undercarboxylated osteocalcin correlates with insulin secretion in Japanese individuals with diabetes

Funakoshi

Yoshimura

Hirano

et al. 2020

Diabetol Metab Syndr

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Background: Undercarboxylated osteocalcin (ucOC) is a secreted protein produced by osteoblasts that regulates insulin secretion and insulin sensitivity in rodents. However, the significance of these effects on glucose metabolism in human remains unknown. Moreover, the pathophysiological roles of ucOC on varying degrees of glucose intolerance, including diabetes need to be elucidated. In the present study, correlations between ucOC and indices of insulin secretion and sensitivity were analyzed in normal glucose tolerance (NGT), impaired glucose metabolism (IGM), and diabetes mellitus (DM) groups. Methods: Based on 75 g OGTT data in Japanese individuals without diabetic medication, or medications which may affect ucOC levels, individuals were classified as having normal glucose tolerance (NGT), impaired glucose metabolism (IGM), or diabetes (DM). In each group, 25 individuals were consecutively recruited [total 75 individuals, age: 65 ± 11 (mean ± SD); BMI: 24.9 ± 3.8 kg/m 2 ]. QUICKI and Matsuda index (MI) were calculated as insulin sensitivity indices. Homeostasis model assessment (HOMA)-β and insulinogenic index (IGI) were calculated as insulin secretion indices. UcOC was measured using ECLIA. Normally-distributed log e-transformed (ln-) values were used for ucOC, HOMA-β, IGI, and MI. Results: The ucOC was not significantly different among the three groups. The results of multiple regression analysis showed that ln-ucOC did not significantly correlate with age, sex, BMI, waist circumference, fasting plasma glucose, plasma glucose 120 min after glucose loading, fasting plasma immunoreactive insulin, ln-HOMA-β, QUICKI, or ln-MI in any of the three groups. Interestingly, ln-ucOC correlated with ln-IGI (r = 0.422, P = 0.0354) and HbA1c (r = − 0.574, P = 0.0027) only in the DM group. There was no significant correlation between ln-IGI and age, sex, BMI, or HbA1c in the DM group. Further, the results of multiple regression analysis showed that ln-IGI could be independently predicted by BMI (β = 0.598, P = 0.0014) and ln-ucOC (β = 0.641, P = 0.0007) in the DM group (R 2 = 0.488, P = 0.0006). Conclusion: In our study, ucOC positively correlated with insulin secretion independently of BMI in Japanese individuals with diabetes. These results suggest that ucOC plays more important roles in insulin secretion than in insulin sensitivity in individuals with diabetes.

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Section: Methodsmentioning

confidence: 99%

Undercarboxylated osteocalcin correlates with insulin secretion in Japanese individuals with diabetes

Funakoshi

Yoshimura

Hirano

et al. 2020

Diabetol Metab Syndr

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“…Indices of insulin secretion and insulin sensitivity were calculated using glucose and IRI data from the 75-g OGTT, as previously described [ 7 , 10 ]. QUICKI and Matsuda index (MI) were calculated as indices of insulin sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Amano

Funakoshi

Yoshimura

et al. 2018

Diabetol Metab Syndr

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BackgroundRecently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M0) are associated with insulin resistance independent of BMI. Since the association between mannose and insulin sensitivity (IS) in those with impaired glucose tolerance remains unknown, we aimed to investigate this association in individuals without severe obesity but with varying degrees of glucose tolerance.MethodsBased on 75 g OGTT data in Japanese individuals without diabetic medication, individuals were classified as having normal glucose tolerance (NGT), impaired glucose metabolism (IGM), or diabetes (DM). In each group, 25 individuals were consecutively recruited [total 75 individuals, age: 65 ± 11 (mean ± SD); BMI: 24.9 ± 3.8 kg/m2]. QUICKI and Matsuda index (MI) were calculated as IS indices. M0 was assayed using HPLC. Normally-distributed loge-transformed (ln-) values were used for MI and leptin.ResultsIn the simple regression analysis, ln-MI was negatively correlated with BMI (NGT: r = − 0.639, IGM: r = − 0.466, DM: r = − 0.613) and ln-leptin (NGT: r = − 0.480, IGT: r = − 0.447, DM: r = − 0.593) in all 3 groups. Ln-MI was not significantly correlated with M0 in NGT (r = 0.241, P = 0.245) and IGT (r = − 0.296, P = 0.152) groups, it was moderately and negatively correlated in the DM group (r = − 0.626, P < 0.001). Similar results were obtained, when QUICKI was used instead of MI as an index of IS. In multiple regression analysis in the DM group, QUICKI (Q) and ln-MI (M) were independently predicted by BMI (Q: β = − 0.413; M: β = − 0.400) and M0 (Q: β = − 0.413, M: β = − 0.426), accounting for 51.2% (P = 0.0004) and 51.2% (P = 0.0004) of the variability, respectively, which was larger than the prediction for BMI alone (Q: 38.4%, M: 37.6%).ConclusionFasting plasma mannose was associated with IS independent of BMI in Japanese individuals with DM.

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“…тит, стеатофиброз, цирроз и гепатоцеллюлярную карциному [4][5][6][7][8]. К явно недооцененным факторам развития НАЖБП относится дисбаланс в тиреоидном статусе при заболеваниях щитовидной железы, в частности при гипотиреозе, при том, что оба заболевания имеют общие «точки соприкосновения» через инсулинорезистентность, дисипидемию, метаболический синдром и ожирение [9,10].…”

Section: клинические исследованияunclassified

Non-alcoholic Fatty Liver Disease and Postoperative Hypothyroidism in Women: Clinical and Pathogenetic Parallels

Dzhulay¹,

Shchelochenkov²,

Guskova³

2021

EPh

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Objective – to establish the clinical and pathogenetic patterns of the formation and course of non-alcoholic fatty liver disease in women with postoperative hypothyroidism. Material and methods. In a single-stage study of the "case-control" type of 170 women (Me aged 50 years), anthropometric data, parameters of carbohydrate, lipid, and protein metabolism, liver function tests were studied in the presence and absence of postoperative hypothyroidism. Results. It was found that in 86.2% of women with postoperative hypothyroidism, non-alcoholic fatty liver disease develops mainly in the form of steatohepatosis without distinct functional liver disorders. Insulin resistance and atherogenic dyslipidemia are found in the vast majority of them, the degree of their severity is determined by the presence of excess body weight with android and intermediate types of fat distribution. The greatest diagnostic value in the aspect of the probability of developing non-alcoholic fatty liver disease and metabolic disorders have a body mass index of Ketle and the ratio of the waist to the circumference of the hips. For the detection of metabolic disorders, the most significant insulin resistance index HOMA-IR, HDL, VLDL, ApoB, ApoB/ApoA1 index. Conclusion. In women with postoperative hypothyroidism in 86.2% of cases non-alcoholic fatty liver disease develops mainly in the form of steatohepatosis, characterized by a oligosymptomatic course without distinct functional liver disorders, the development of insulin resistance and atherogenic dyslipidemia, the severity of which is determined by the body mass index and the type of fat distribution

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Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

Cited by 10 publications

References 42 publications

Undercarboxylated osteocalcin correlates with insulin secretion in Japanese individuals with diabetes

Undercarboxylated osteocalcin correlates with insulin secretion in Japanese individuals with diabetes

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Non-alcoholic Fatty Liver Disease and Postoperative Hypothyroidism in Women: Clinical and Pathogenetic Parallels

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